Seroatlas · Human Serome Atlas

MPRIP

Myosin phosphatase Rho-interacting protein

Also known as: M-RIP, MPRIP_HUMAN, p116Rip, RHOIP3

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6WCQ1
Gene: MPRIP
Ensembl: ENSG00000133030
Chromosome: 17
Canonical length: 1025 aa
Protein class: Predicted intracellular proteins
Subcellular location: Actin filaments,Cytosol

OverviewNCBI Gene

Enables cadherin binding activity. Located in actin cytoskeleton and cytosol. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1025 residues, UniProt reviewed canonical sequence.

>Q6WCQ1|MPRIP
     1  MSAAKENPCR KFQANIFNKS KCQNCFKPRE SHLLNDEDLT QAKPIYGGWL LLAPDGTDFD
    61  NPVHRSRKWQ RRFFILYEHG LLRYALDEMP TTLPQGTINM NQCTDVVDGE GRTGQKFSLC
   121  ILTPEKEHFI RAETKEIVSG WLEMLMVYPR TNKQNQKKKR KVEPPTPQEP GPAKVAVTSS
   181  SSSSSSSSSI PSAEKVPTTK STLWQEEMRT KDQPDGSSLS PAQSPSQSQP PAASSLREPG
   241  LESKEEESAM SSDRMDCGRK VRVESGYFSL EKTKQDLKAE EQQLPPPLSP PSPSTPNHRR
   301  SQVIEKFEAL DIEKAEHMET NAVGPSPSSD TRQGRSEKRA FPRKRDFTNE APPAPLPDAS
   361  ASPLSPHRRA KSLDRRSTEP SVTPDLLNFK KGWLTKQYED GQWKKHWFVL ADQSLRYYRD
   421  SVAEEAADLD GEIDLSACYD VTEYPVQRNY GFQIHTKEGE FTLSAMTSGI RRNWIQTIMK
   481  HVHPTTAPDV TSSLPEEKNK SSCSFETCPR PTEKQEAELG EPDPEQKRSR ARERRREGRS
   541  KTFDWAEFRP IQQALAQERV GGVGPADTHE PLRPEAEPGE LERERARRRE ERRKRFGMLD
   601  ATDGPGTEDA ALRMEVDRSP GLPMSDLKTH NVHVEIEQRW HQVETTPLRE EKQVPIAPVH
   661  LSSEDGGDRL STHELTSLLE KELEQSQKEA SDLLEQNRLL QDQLRVALGR EQSAREGYVL
   721  QATCERGFAA MEETHQKKIE DLQRQHQREL EKLREEKDRL LAEETAATIS AIEAMKNAHR
   781  EEMERELEKS QRSQISSVNS DVEALRRQYL EELQSVQREL EVLSEQYSQK CLENAHLAQA
   841  LEAERQALRQ CQRENQELNA HNQELNNRLA AEITRLRTLL TGDGGGEATG SPLAQGKDAY
   901  ELEVLLRVKE SEIQYLKQEI SSLKDELQTA LRDKKYASDK YKDIYTELSI AKAKADCDIS
   961  RLKEQLKAAT EALGEKSPDS ATVSGYDIMK SKSNPDFLKK DRSCVTRQLR NIRSKSVIEQ
  1021  VSWDT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MPRIP can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.53
Highest tissue expression: 312 nTPM

Expression across tissuesHPA

Tissue

blood vessel: 312 nTPM
heart muscle: 231 nTPM
endometrium: 161 nTPM
skeletal muscle: 160 nTPM
basal ganglia: 153 nTPM
midbrain: 149 nTPM

Single-cell type

esophageal apical cells: 490 nCPM
endometrial glandular cells: 396 nCPM
urothelial cells: 390 nCPM
endometrial luminal cells: 332 nCPM
alveolar cells type 1: 329 nCPM
sertoli cells: 262 nCPM

Immune cell

T-reg: 61 nTPM
memory CD4 T-cell: 35 nTPM
naive CD4 T-cell: 25 nTPM
MAIT T-cell: 18 nTPM
memory CD8 T-cell: 14 nTPM
naive CD8 T-cell: 12 nTPM

Brain region

basal ganglia: 396 nTPM
hippocampal formation: 339 nTPM
cerebral cortex: 336 nTPM
thalamus: 318 nTPM
pons: 308 nTPM
amygdala: 301 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.3
gnomAD pLI: 0.98
gnomAD missense Z: 1.81
DepMap mean gene effect: -0.27
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of MPRIP in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MPRIP as an antibody target. Whether an autoantibody or antibody against MPRIP could matter depends on whether native MPRIP is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MPRIP is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MPRIP as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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