Seroatlas · Human Serome Atlas

RAI14

Ankycorbin

Also known as: DKFZp564G013, KIAA1334, NORPEG, RAI13, RAI14_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9P0K7
Gene: RAI14
Ensembl: ENSG00000039560
Chromosome: 5
Canonical length: 980 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Actin filaments,Cytosol

OverviewNCBI Gene

Predicted to enable actin binding activity. Predicted to be involved in cell differentiation and spermatogenesis. Located in cytosol; fibrillar center; and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

980 residues, UniProt reviewed canonical sequence.

>Q9P0K7|RAI14
     1  MKSLKAKFRK SDTNEWNKND DRLLQAVENG DAEKVASLLG KKGASATKHD SEGKTAFHLA
    61  AAKGHVECLR VMITHGVDVT AQDTTGHSAL HLAAKNSHHE CIRKLLQSKC PAESVDSSGK
   121  TALHYAAAQG CLQAVQILCE HKSPINLKDL DGNIPLLLAV QNGHSEICHF LLDHGADVNS
   181  RNKSGRTALM LACEIGSSNA VEALIKKGAD LNLVDSLGYN ALHYSKLSEN AGIQSLLLSK
   241  ISQDADLKTP TKPKQHDQVS KISSERSGTP KKRKAPPPPI SPTQLSDVSS PRSITSTPLS
   301  GKESVFFAEP PFKAEISSIR ENKDRLSDST TGADSLLDIS SEADQQDLLS LLQAKVASLT
   361  LHNKELQDKL QAKSPKEAEA DLSFDSYHST QTDLGPSLGK PGETSPPDSK SSPSVLIHSL
   421  GKSTTDNDVR IQQLQEILQD LQKRLESSEA ERKQLQVELQ SRRAELVCLN NTEISENSSD
   481  LSQKLKETQS KYEEAMKEVL SVQKQMKLGL VSPESMDNYS HFHELRVTEE EINVLKQDLQ
   541  NALEESERNK EKVRELEEKL VEREKGTVIK PPVEEYEEMK SSYCSVIENM NKEKAFLFEK
   601  YQEAQEEIMK LKDTLKSQMT QEASDEAEDM KEAMNRMIDE LNKQVSELSQ LYKEAQAELE
   661  DYRKRKSLED VTAEYIHKAE HEKLMQLTNV SRAKAEDALS EMKSQYSKVL NELTQLKQLV
   721  DAQKENSVSI TEHLQVITTL RTAAKEMEEK ISNLKEHLAS KEVEVAKLEK QLLEEKAAMT
   781  DAMVPRSSYE KLQSSLESEV SVLASKLKES VKEKEKVHSE VVQIRSEVSQ VKREKENIQT
   841  LLKSKEQEVN ELLQKFQQAQ EELAEMKRYA ESSSKLEEDK DKKINEMSKE VTKLKEALNS
   901  LSQLSYSTSS SKRQSQQLEA LQQQVKQLQN QLAECKKQHQ EVISVYRMHL LYAVQGQMDE
   961  DVQKVLKQIL TMCKNQSQKK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RAI14 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.47
Highest tissue expression: 54 nTPM

Expression across tissuesHPA

Tissue

smooth muscle: 54 nTPM
endometrium: 50 nTPM
cervix: 48 nTPM
urinary bladder: 40 nTPM
spleen: 37 nTPM
testis: 37 nTPM

Single-cell type

late spermatids: 575 nCPM
syncytiotrophoblasts: 572 nCPM
salivary duct cells: 419 nCPM
conjunctival goblet cells: 416 nCPM
early spermatids: 392 nCPM
breast lactating cells: 357 nCPM

Immune cell

basophil: 0.9 nTPM
gdT-cell: 0.9 nTPM
NK-cell: 0.8 nTPM
neutrophil: 0.4 nTPM
classical monocyte: 0.2 nTPM
memory CD4 T-cell: 0.2 nTPM

Brain region

white matter: 40 nTPM
medulla oblongata: 38 nTPM
choroid plexus: 37 nTPM
spinal cord: 33 nTPM
pons: 32 nTPM
basal ganglia: 29 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.29
gnomAD pLI: 0.99
gnomAD missense Z: 1.62
DepMap mean gene effect: 0.11
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

actin binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RAI14 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RAI14 as an antibody target. Whether an autoantibody or antibody against RAI14 could matter depends on whether native RAI14 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RAI14 is annotated at the cell surface, where native RAI14 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label RAI14 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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