Seroatlas · Human Serome Atlas

GPR37

Prosaposin receptor GPR37

Also known as: EDNRBL, GPR37_HUMAN, hET(B)R-LP, PAELR

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O15354
Gene
GPR37
Ensembl
ENSG00000170775
Chromosome
7
Canonical length
613 aa
Protein class
G-protein coupled receptors, Predicted membrane proteins, Transporters
Subcellular location
Nuclear membrane,Nucleoli,Cytosol

OverviewNCBI Gene

This gene is a member of the G protein-coupled receptor family. The encoded protein contains seven transmembrane domains and is found in cell and endoplasmic reticulum membranes. G protein-coupled receptors are involved in translating outside signals into G protein mediated intracellular effects. This gene product interacts with Parkin and is involved in juvenile Parkinson disease. [provided by RefSeq, Oct 2012]

Canonical amino-acid sequenceUniProt

613 residues, UniProt reviewed canonical sequence.

>O15354|GPR37
     1  MRAPGALLAR MSRLLLLLLL KVSASSALGV APASRNETCL GESCAPTVIQ RRGRDAWGPG
    61  NSARDVLRAR APREEQGAAF LAGPSWDLPA APGRDPAAGR GAEASAAGPP GPPTRPPGPW
   121  RWKGARGQEP SETLGRGNPT ALQLFLQISE EEEKGPRGAG ISGRSQEQSV KTVPGASDLF
   181  YWPRRAGKLQ GSHHKPLSKT ANGLAGHEGW TIALPGRALA QNGSLGEGIH EPGGPRRGNS
   241  TNRRVRLKNP FYPLTQESYG AYAVMCLSVV IFGTGIIGNL AVMCIVCHNY YMRSISNSLL
   301  ANLAFWDFLI IFFCLPLVIF HELTKKWLLE DFSCKIVPYI EVASLGVTTF TLCALCIDRF
   361  RAATNVQMYY EMIENCSSTT AKLAVIWVGA LLLALPEVVL RQLSKEDLGF SGRAPAERCI
   421  IKISPDLPDT IYVLALTYDS ARLWWYFGCY FCLPTLFTIT CSLVTARKIR KAEKACTRGN
   481  KRQIQLESQM NCTVVALTIL YGFCIIPENI CNIVTAYMAT GVSQQTMDLL NIISQFLLFF
   541  KSCVTPVLLF CLCKPFSRAF MECCCCCCEE CIQKSSTVTS DDNDNEYTTE LELSPFSTIR
   601  REMSTFASVG THC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GPR37 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
7
Mean surface accessibility (rSASA)
0.49
Highest tissue expression
67 nTPM

Expression across tissuesHPA

Tissue

  • spinal cord: 67 nTPM
  • retina: 36 nTPM
  • hippocampal formation: 31 nTPM
  • midbrain: 27 nTPM
  • cerebral cortex: 27 nTPM
  • basal ganglia: 26 nTPM

Single-cell type

  • müller glia: 787 nCPM
  • oligodendrocytes: 380 nCPM
  • retinal bipolar cells: 82 nCPM
  • retinal horizontal cells: 52 nCPM
  • schwann cells: 39 nCPM
  • sertoli cells: 38 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • white matter: 219 nTPM
  • basal ganglia: 129 nTPM
  • medulla oblongata: 128 nTPM
  • midbrain: 113 nTPM
  • cerebellum: 108 nTPM
  • pons: 101 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.79
gnomAD pLI
0
gnomAD missense Z
0.84
DepMap mean gene effect
0.11
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of GPR37 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GPR37 as an antibody target. Whether an autoantibody or antibody against GPR37 could matter depends on whether native GPR37 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GPR37 is annotated at the cell surface, where native GPR37 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label GPR37 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/GPR37. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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