Seroatlas · Human Serome Atlas

MEIG1

Meiosis expressed gene 1 protein homolog

Also known as: bA2K17.3, MEIG1_HUMAN, SPATA39

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5JSS6
Gene: MEIG1
Ensembl: ENSG00000197889
Chromosome: 10
Canonical length: 88 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Predicted to be involved in cell differentiation. Predicted to act upstream of or within manchette assembly and protein localization. Predicted to be located in cytosol and manchette. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

88 residues, UniProt reviewed canonical sequence.

>Q5JSS6|MEIG1
     1  MASSDVKPKS VSHAKKWSEE IENLYRFQQA GYRDETEYRQ VKQVSMVDRW PETGYVKKLQ
    61  RRDNTFYYYN KQRECDDKEV HKVKIYAY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MEIG1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.35
Highest tissue expression: 9.5 nTPM

Expression across tissuesHPA

Tissue

testis: 9.5 nTPM
fallopian tube: 3.4 nTPM
basal ganglia: 1.2 nTPM
midbrain: 1.1 nTPM
hypothalamus: 1 nTPM
amygdala: 0.9 nTPM

Single-cell type

late primary spermatocytes: 164 nCPM
early spermatids: 116 nCPM
respiratory ciliated cells: 54 nCPM
fallopian tube ciliated cells: 45 nCPM
endometrial ciliated cells: 33 nCPM
ependymal cells: 25 nCPM

Immune cell

memory B-cell: 1.4 nTPM
T-reg: 0.7 nTPM
NK-cell: 0.4 nTPM
non-classical monocyte: 0.3 nTPM
MAIT T-cell: 0.2 nTPM
memory CD4 T-cell: 0.2 nTPM

Brain region

midbrain: 1.6 nTPM
choroid plexus: 1.3 nTPM
medulla oblongata: 1.3 nTPM
white matter: 1.2 nTPM
spinal cord: 1.1 nTPM
hypothalamus: 0.9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.84
gnomAD pLI: 0
gnomAD missense Z: -0.23
DepMap mean gene effect: 0.14
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

Meiosis-expressed gene 1 protein
Meiosis-expressed

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of MEIG1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MEIG1 as an antibody target. Whether an autoantibody or antibody against MEIG1 could matter depends on whether native MEIG1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MEIG1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MEIG1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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