Creatinase/aminopeptidase-like
IPR036005
Definition
This entry contains proteins that belong to MEROPS peptidase family M24 (clan MG), which share a common structural-fold, the "pita-bread" fold. The fold contains both α helices and an anti-parallel β sheet within two structurally similar domains that are thought to be derived from an ancient gene duplication. The active site, where conserved, is located between the two domains. The fold is common to methionine aminopeptidase ([ec:3.4.11.18]), aminopeptidase P ([ec:3.4.11.9]), prolidase ([ec:3.4.13.9]), agropine synthase and creatinase ([ec:3.5.3.3]). Though many of these peptidases require a divalent cation, creatinase is not a metal-dependent enzyme [[cite:PMID:8146141], [cite:PMID:12136144], [cite:PMID:8471602]].
9 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
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