Seroatlas · Human Serome Atlas

PLSCR1

Phospholipid scramblase 1

Also known as: MMTRA1B, PLS1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O15162
Gene
PLSCR1
Ensembl
ENSG00000188313
Chromosome
3
Canonical length
318 aa
Protein class
Predicted intracellular proteins, Transporters
Subcellular location
Nucleoplasm,Golgi apparatus,Plasma membrane
Quaternary structure
Homodimer

OverviewNCBI Gene

This gene encodes a phospholipid scramblase family member. The encoded protein is involved in disruption of the asymmetrical distribution of phospholipids between the inner and outer leaflets of the plasma membrane, resulting in externalization of phosphatidylserine. This cell membrane disruption plays an important role in the blood coagulation cascade as well as macrophage clearing of apoptotic cells. The encoded protein has additionally been implicated in gene regulation and interferon-induced antiviral responses. [provided by RefSeq, May 2022]

Canonical amino-acid sequenceUniProt

318 residues, UniProt reviewed canonical sequence.

>O15162|PLSCR1
     1  MDKQNSQMNA SHPETNLPVG YPPQYPPTAF QGPPGYSGYP GPQVSYPPPP AGHSGPGPAG
    61  FPVPNQPVYN QPVYNQPVGA AGVPWMPAPQ PPLNCPPGLE YLSQIDQILI HQQIELLEVL
   121  TGFETNNKYE IKNSFGQRVY FAAEDTDCCT RNCCGPSRPF TLRIIDNMGQ EVITLERPLR
   181  CSSCCCPCCL QEIEIQAPPG VPIGYVIQTW HPCLPKFTIQ NEKREDVLKI SGPCVVCSCC
   241  GDVDFEIKSL DEQCVVGKIS KHWTGILREA FTDADNFGIQ FPLDLDVKMK AVMIGACFLI
   301  DFMFFESTGS QEQKSGVW

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PLSCR1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.41
Highest tissue expression
82 nTPM

Expression across tissuesHPA

Tissue

  • appendix: 82 nTPM
  • urinary bladder: 64 nTPM
  • gallbladder: 62 nTPM
  • bone marrow: 61 nTPM
  • colon: 61 nTPM
  • spleen: 61 nTPM

Single-cell type

  • neutrophils: 830 nCPM
  • esophageal apical cells: 626 nCPM
  • neutrophil progenitors: 470 nCPM
  • monocytes: 403 nCPM
  • urothelial cells: 305 nCPM
  • fallopian secretory cells: 252 nCPM

Immune cell

  • intermediate monocyte: 160 nTPM
  • classical monocyte: 158 nTPM
  • myeloid DC: 106 nTPM
  • neutrophil: 100 nTPM
  • non-classical monocyte: 95 nTPM
  • total PBMC: 79 nTPM

Brain region

  • medulla oblongata: 21 nTPM
  • spinal cord: 18 nTPM
  • pons: 17 nTPM
  • thalamus: 15 nTPM
  • white matter: 14 nTPM
  • midbrain: 13 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.73
gnomAD pLI
0.01
gnomAD missense Z
0.87
DepMap mean gene effect
0.08
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PLSCR1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PLSCR1 as an antibody target. Whether an autoantibody or antibody against PLSCR1 could matter depends on whether native PLSCR1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PLSCR1 is annotated at the cell surface, where native PLSCR1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label PLSCR1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PLSCR1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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