ELL/occludin family
IPR031176
Definition
This entry represents the ELL/occludin family. Occludin is found in the tight junction and may play a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier PMID:19114660. ELL is a family of RNA polymerase II elongation factors. It is bound stably to elongation-associated factors 1 and 2, EAFs, and together these act as a strong regulator of transcription activity by direct interaction with Pol II. ELL binds to pol II on its own but the affinity is greatly increased by the cooperation of EAF PMID:17150956.
6 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
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