ILDR2

Protein identityUniProt · HPA

UniProt accession

Q71H61

Gene

ILDR2

Ensembl

ENSG00000143195

Chromosome

1

Canonical length

639 aa

Protein class

Predicted intracellular proteins, Predicted membrane proteins

Subcellular location

Plasma membrane

OverviewNCBI Gene

Involved in negative regulation of T cell activation. Predicted to be located in tight junction. Predicted to be active in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

639 residues, UniProt reviewed canonical sequence.

>Q71H61|ILDR2
     1  MDRVLLRWIS LFWLTAMVEG LQVTVPDKKK VAMLFQPTVL RCHFSTSSHQ PAVVQWKFKS
    61  YCQDRMGESL GMSSTRAQSL SKRNLEWDPY LDCLDSRRTV RVVASKQGST VTLGDFYRGR
   121  EITIVHDADL QIGKLMWGDS GLYYCIITTP DDLEGKNEDS VELLVLGRTG LLADLLPSFA
   181  VEIMPEWVFV GLVLLGVFLF FVLVGICWCQ CCPHSCCCYV RCPCCPDSCC CPQALYEAGK
   241  AAKAGYPPSV SGVPGPYSIP SVPLGGAPSS GMLMDKPHPP PLAPSDSTGG SHSVRKGYRI
   301  QADKERDSMK VLYYVEKELA QFDPARRMRG RYNNTISELS SLHEEDSNFR QSFHQMRSKQ
   361  FPVSGDLESN PDYWSGVMGG SSGASRGPSA MEYNKEDRES FRHSQPRSKS EMLSRKNFAT
   421  GVPAVSMDEL AAFADSYGQR PRRADGNSHE ARGGSRFERS ESRAHSGFYQ DDSLEEYYGQ
   481  RSRSREPLTD ADRGWAFSPA RRRPAEDAHL PRLVSRTPGT APKYDHSYLG SARERQARPE
   541  GASRGGSLET PSKRSAQLGP RSASYYAWSP PGTYKAGSSQ DDQEDASDDA LPPYSELELT
   601  RGPSYRGRDL PYHSNSEKKR KKEPAKKTND FPTRMSLVV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ILDR2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Cell surface

Secreted

No

Transmembrane segments

1

Mean surface accessibility (rSASA)

0.59

Highest tissue expression

9.8 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about ILDR2.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 103 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

• Moyamoya angiopathy

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.34

gnomAD pLI

0.95

gnomAD missense Z

1.26

DepMap mean gene effect

0.02

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• cell differentiation
• homeostasis of number of cells within a tissue
• insulin secretion
• negative regulation of T cell activation
• pancreas development
• regulation of RNA splicing
• response to glucose

Cellular components

• bicellular tight junction
• endoplasmic reticulum membrane
• membrane
• nucleus
• tight junction

Protein domainsUniProt · Pfam · InterPro

• Immunoglobulin domain subtype
• LISCH7
• Immunoglobulin-like fold
• Immunoglobulin-like domain superfamily
• Immunoglobulin-like domain-containing protein LISCH7
• Lipolysis stimulated receptor (LSR)

KeywordsUniProt

• Cell junction
• Disulfide bond
• Endoplasmic reticulum
• Immunoglobulin domain
• Membrane
• Methylation
• Nucleus
• Phosphoprotein
• Signal
• Tight junction
• Transmembrane
• Transmembrane helix

InteractionsUniProt · HPA

Protein binding partners of ILDR2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• MARVELD2
• OCLN
• P4HB
• HSPA5