Seroatlas · Human Serome Atlas

CLDN6

Claudin-6

Also known as: CLD6_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P56747
Gene
CLDN6
Ensembl
ENSG00000184697
Chromosome
16
Canonical length
220 aa
Protein class
Predicted intracellular proteins, Predicted membrane proteins

OverviewNCBI Gene

Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. This gene encodes a component of tight junction strands, which is a member of the claudin family. The protein is an integral membrane protein and is one of the entry cofactors for hepatitis C virus. The gene methylation may be involved in esophageal tumorigenesis. This gene is adjacent to another family member CLDN9 on chromosome 16.[provided by RefSeq, Aug 2010]

Canonical amino-acid sequenceUniProt

220 residues, UniProt reviewed canonical sequence.

>P56747|CLDN6
     1  MASAGMQILG VVLTLLGWVN GLVSCALPMW KVTAFIGNSI VVAQVVWEGL WMSCVVQSTG
    61  QMQCKVYDSL LALPQDLQAA RALCVIALLV ALFGLLVYLA GAKCTTCVEE KDSKARLVLT
   121  SGIVFVISGV LTLIPVCWTA HAIIRDFYNP LVAEAQKREL GASLYLGWAA SGLLLLGGGL
   181  LCCTCPSGGS QGPSHYMARY STSAPAISRG PSEYPTKNYV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CLDN6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
4
Mean surface accessibility (rSASA)
0.37
Highest tissue expression
1 nTPM

Expression across tissuesHPA

Tissue

  • basal ganglia: 1 nTPM
  • pancreas: 1 nTPM
  • testis: 0.8 nTPM
  • cerebellum: 0.7 nTPM
  • placenta: 0.7 nTPM
  • kidney: 0.3 nTPM

Single-cell type

  • extravillous trophoblasts: 174 nCPM
  • migrating cytotrophoblasts: 157 nCPM
  • syncytiotrophoblasts: 41 nCPM
  • epididymal basal cells: 39 nCPM
  • epididymal efferent duct absorptive cells: 32 nCPM
  • pancreatic duct cells: 29 nCPM

Immune cell

  • neutrophil: 0.1 nTPM
  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM

Brain region

  • cerebellum: 4.9 nTPM
  • basal ganglia: 4.5 nTPM
  • choroid plexus: 4 nTPM
  • amygdala: 3.9 nTPM
  • cerebral cortex: 3.9 nTPM
  • hippocampal formation: 3.8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.58
gnomAD pLI
0
gnomAD missense Z
-0.43
DepMap mean gene effect
-0.21
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CLDN6 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CLDN6 as an antibody target. Whether an autoantibody or antibody against CLDN6 could matter depends on whether native CLDN6 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CLDN6 is annotated at the cell surface, where native CLDN6 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label CLDN6 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CLDN6. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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