Seroatlas · Human Serome Atlas

CLDN17

Claudin-17

Also known as: CLD17_HUMAN, MGC126552, MGC126554

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P56750
Gene: CLDN17
Ensembl: ENSG00000156282
Chromosome: 21
Canonical length: 224 aa
Protein class: Predicted membrane proteins, Transporters

OverviewNCBI Gene

This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This gene is intronless and is clustered with CLDN8 on chromosome 21q22.11. [provided by RefSeq, Jun 2010]

Canonical amino-acid sequenceUniProt

224 residues, UniProt reviewed canonical sequence.

>P56750|CLDN17
     1  MAFYPLQIAG LVLGFLGMVG TLATTLLPQW RVSAFVGSNI IVFERLWEGL WMNCIRQARV
    61  RLQCKFYSSL LALPPALETA RALMCVAVAL SLIALLIGIC GMKQVQCTGS NERAKAYLLG
   121  TSGVLFILTG IFVLIPVSWT ANIIIRDFYN PAIHIGQKRE LGAALFLGWA SAAVLFIGGG
   181  LLCGFCCCNR KKQGYRYPVP GYRVPHTDKR RNTTMLSKTS TSYV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CLDN17 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 4
Mean surface accessibility (rSASA): 0.37
Highest tissue expression: 6.9 nTPM

Expression across tissuesHPA

Tissue

vagina: 6.9 nTPM
cervix: 6.4 nTPM
esophagus: 6.1 nTPM
salivary gland: 5.5 nTPM
tonsil: 1.2 nTPM
testis: 0.3 nTPM

Single-cell type

esophageal apical cells: 95 nCPM
early spermatids: 4.5 nCPM
suprabasal keratinocytes: 3.4 nCPM
late primary spermatocytes: 1.9 nCPM
esophageal suprabasal cells: 1.8 nCPM
late spermatids: 1.8 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

amygdala: 0 nTPM
basal ganglia: 0 nTPM
cerebellum: 0 nTPM
cerebral cortex: 0 nTPM
choroid plexus: 0 nTPM
hippocampal formation: 0 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.83
gnomAD pLI: 0
gnomAD missense Z: -0.26
DepMap mean gene effect: 0.14
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CLDN17 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

OCLN

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CLDN17 as an antibody target. Whether an autoantibody or antibody against CLDN17 could matter depends on whether native CLDN17 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CLDN17 is annotated at the cell surface, where native CLDN17 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label CLDN17 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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