Seroatlas · Human Serome Atlas

LSR

Lipolysis-stimulated lipoprotein receptor

Also known as: ILDR3, LISCH7, LSR_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q86X29
Gene
LSR
Ensembl
ENSG00000105699
Chromosome
19
Canonical length
649 aa
Protein class
Disease related genes, Predicted intracellular proteins, Predicted membrane proteins
Subcellular location
Plasma membrane,Cell Junctions
Quaternary structure
Homotetramer

OverviewNCBI Gene

Predicted to be involved in several processes, including establishment of skin barrier; protein localization to tricellular tight junction; and tricellular tight junction assembly. Predicted to act upstream of or within maintenance of blood-brain barrier. Located in plasma membrane and tight junction. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

649 residues, UniProt reviewed canonical sequence.

>Q86X29|LSR
     1  MQQDGLGVGT RNGSGKGRSV HPSWPWCAPR PLRYFGRDAR ARRAQTAAMA LLAGGLSRGL
    61  GSHPAAAGRD AVVFVWLLLS TWCTAPARAI QVTVSNPYHV VILFQPVTLP CTYQMTSTPT
   121  QPIVIWKYKS FCRDRIADAF SPASVDNQLN AQLAAGNPGY NPYVECQDSV RTVRVVATKQ
   181  GNAVTLGDYY QGRRITITGN ADLTFDQTAW GDSGVYYCSV VSAQDLQGNN EAYAELIVLG
   241  RTSGVAELLP GFQAGPIEDW LFVVVVCLAA FLIFLLLGIC WCQCCPHTCC CYVRCPCCPD
   301  KCCCPEALYA AGKAATSGVP SIYAPSTYAH LSPAKTPPPP AMIPMGPAYN GYPGGYPGDV
   361  DRSSSAGGQG SYVPLLRDTD SSVASEVRSG YRIQASQQDD SMRVLYYMEK ELANFDPSRP
   421  GPPSGRVERA MSEVTSLHED DWRSRPSRGP ALTPIRDEEW GGHSPRSPRG WDQEPAREQA
   481  GGGWRARRPR ARSVDALDDL TPPSTAESGS RSPTSNGGRS RAYMPPRSRS RDDLYDQDDS
   541  RDFPRSRDPH YDDFRSRERP PADPRSHHHR TRDPRDNGSR SGDLPYDGRL LEEAVRKKGS
   601  EERRRPHKEE EEEAYYPPAP PPYSETDSQA SRERRLKKNL ALSRESLVV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LSR can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.6
Highest tissue expression
139 nTPM

Expression across tissuesHPA

Tissue

  • liver: 139 nTPM
  • stomach: 125 nTPM
  • pancreas: 111 nTPM
  • colon: 91 nTPM
  • duodenum: 80 nTPM
  • small intestine: 71 nTPM

Single-cell type

  • retinal pigment epithelial cells: 362 nCPM
  • colonocytes: 295 nCPM
  • syncytiotrophoblasts: 286 nCPM
  • cytotrophoblasts: 246 nCPM
  • esophageal apical cells: 229 nCPM
  • urothelial cells: 228 nCPM

Immune cell

  • basophil: 6.4 nTPM
  • memory CD4 T-cell: 5.8 nTPM
  • NK-cell: 5.6 nTPM
  • memory CD8 T-cell: 5.4 nTPM
  • naive CD8 T-cell: 4.9 nTPM
  • memory B-cell: 4.3 nTPM

Brain region

  • choroid plexus: 78 nTPM
  • thalamus: 33 nTPM
  • medulla oblongata: 30 nTPM
  • pons: 28 nTPM
  • amygdala: 28 nTPM
  • midbrain: 26 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about LSR.

Disease | GeneticClinVar

3 pathogenic / likely-pathogenic of 250 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.87
gnomAD pLI
0
gnomAD missense Z
-0.63
DepMap mean gene effect
0.07
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of LSR in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LSR as an antibody target. Whether an autoantibody or antibody against LSR could matter depends on whether native LSR is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LSR is annotated at the cell surface, where native LSR is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label LSR as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/LSR. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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