Seroatlas · Human Serome Atlas

CLDN11

Claudin-11

Also known as: CLD11_HUMAN, OSP, OTM

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O75508
Gene
CLDN11
Ensembl
ENSG00000013297
Chromosome
3
Canonical length
207 aa
Protein class
Disease related genes, Human disease related genes, Predicted membrane proteins
Subcellular location
Lipid droplets,Cell Junctions

OverviewNCBI Gene

This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. The protein encoded by this gene is a major component of central nervous system (CNS) myelin and plays an important role in regulating proliferation and migration of oligodendrocytes. Mouse studies showed that the gene deficiency results in deafness and loss of the Sertoli cell epithelial phenotype in the testis. This protein is a tight junction protein at the human blood-testis barrier (BTB), and the BTB disruption is related to a dysfunction of this gene. Alternatively spliced transcript variants encoding different isoforms have been identified.[provided by RefSeq, Aug 2010]

Canonical amino-acid sequenceUniProt

207 residues, UniProt reviewed canonical sequence.

>O75508|CLDN11
     1  MVATCLQVVG FVTSFVGWIG VIVTTSTNDW VVTCGYTIPT CRKLDELGSK GLWADCVMAT
    61  GLYHCKPLVD ILILPGYVQA CRALMIAASV LGLPAILLLL TVLPCIRMGQ EPGVAKYRRA
   121  QLAGVLLILL ALCALVATIW FPVCAHRETT IVSFGYSLYA GWIGAVLCLV GGCVILCCAG
   181  DAQAFGENRF YYTAGSSSPT HAKSAHV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CLDN11 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
4
Mean surface accessibility (rSASA)
0.33
Highest tissue expression
120 nTPM

Expression across tissuesHPA

Tissue

  • spinal cord: 120 nTPM
  • testis: 51 nTPM
  • ovary: 46 nTPM
  • midbrain: 42 nTPM
  • hippocampal formation: 41 nTPM
  • basal ganglia: 26 nTPM

Single-cell type

  • oligodendrocytes: 2.8 nCPM
  • ovarian stromal cells: 1.8 nCPM
  • sertoli cells: 1.4 nCPM
  • breast myoepithelial cells: 0.9 nCPM
  • lymphatic endothelial cells: 0.7 nCPM
  • leydig cells: 0.6 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • medulla oblongata: 285 nTPM
  • white matter: 196 nTPM
  • pons: 145 nTPM
  • spinal cord: 111 nTPM
  • thalamus: 107 nTPM
  • basal ganglia: 106 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about CLDN11.

Disease | AllUniProt

Conditions CLDN11 is implicated in, by any mechanism.

  • Leukodystrophy, hypomyelinating, 22 (HLD22) MIM:619328

Disease | GeneticClinVar

2 pathogenic / likely-pathogenic of 23 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Leukodystrophy, hypomyelinating, 22

Disease | ImmuneIEDB

Conditions an epitope on CLDN11 was assayed in.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.39
gnomAD pLI
0.91
gnomAD missense Z
1.76
DepMap mean gene effect
-0.01
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CLDN11 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CLDN11 as an antibody target. Whether an autoantibody or antibody against CLDN11 could matter depends on whether native CLDN11 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CLDN11 is annotated at the cell surface, where native CLDN11 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label CLDN11 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CLDN11. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...