PRDX3

Protein identityUniProt · HPA

UniProt accession

P30048

Gene

PRDX3

Ensembl

ENSG00000165672

Chromosome

10

Canonical length

256 aa

Protein class

Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins

Subcellular location

Vesicles,Mitochondria

Quaternary structure

Homodimer

OverviewNCBI Gene

This gene encodes a mitochondrial protein with antioxidant function. The protein is similar to the C22 subunit of Salmonella typhimurium alkylhydroperoxide reductase, and it can rescue bacterial resistance to alkylhydroperoxide in E. coli that lack the C22 subunit. The human and mouse genes are highly conserved, and they map to the regions syntenic between mouse and human chromosomes. Sequence comparisons with recently cloned mammalian homologs suggest that these genes consist of a family that is responsible for the regulation of cellular proliferation, differentiation and antioxidant functions. This family member can protect cells from oxidative stress, and it can promote cell survival in prostate cancer. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 1, 3, 13 and 22. [provided by RefSeq, Oct 2014]

Canonical amino-acid sequenceUniProt

256 residues, UniProt reviewed canonical sequence.

>P30048|PRDX3
     1  MAAAVGRLLR ASVARHVSAI PWGISATAAL RPAACGRTSL TNLLCSGSSQ AKLFSTSSSC
    61  HAPAVTQHAP YFKGTAVVNG EFKDLSLDDF KGKYLVLFFY PLDFTFVCPT EIVAFSDKAN
   121  EFHDVNCEVV AVSVDSHFSH LAWINTPRKN GGLGHMNIAL LSDLTKQISR DYGVLLEGSG
   181  LALRGLFIID PNGVIKHLSV NDLPVGRSVE ETLRLVKAFQ YVETHGEVCP ANWTPDSPTI
   241  KPSPAASKEY FQKVNQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PRDX3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.38

Highest tissue expression

534 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about PRDX3.

Disease | AllUniProt

Conditions PRDX3 is implicated in, by any mechanism.

• Spinocerebellar ataxia, autosomal recessive, 32 (SCAR32) MIM:619862
• Corneal dystrophy, punctiform and polychromatic pre-Descemet (PPPCD) MIM:619871

Disease | GeneticClinVar

10 pathogenic / likely-pathogenic of 68 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

• Spinocerebellar ataxia, autosomal recessive 32
• Corneal dystrophy, punctiform and polychromatic pre-descemet
• Autosomal recessive cerebellar ataxia

Disease | ImmuneIEDB

Conditions an epitope on PRDX3 was assayed in.

• skin melanoma T cell

ReferencesPubMed · IEDB

Publications for PRDX3 from three distinct lines of evidence, kept separate because they answer different questions: whether antibodies are directed at the protein, whether a B-cell epitope has been mapped on it, and whether a T-cell epitope has. Each is labelled with its source.

Sources: PubMed — antigen-level antibody evidence from a custom retrieval. Records matching a controlled set of autoantibody terms (the MeSH descriptors Autoantibodies and Autoantigens, with title and abstract term variants) were obtained through NCBI E-utilities, and their titles and abstracts parsed for constructions that direct an antibody at a named protein rather than for co-occurrence. Captured names were resolved against UniProt nomenclature and each antigen adjudicated individually against the source text. IEDB — curated epitope assays from the Immune Epitope Database (Vita et al., Nucleic Acids Research 2019). Bibliographic records from PubMed and MeSH, U.S. National Library of Medicine; citation metrics from NIH iCite (Hutchins et al., PLoS Biology 2016). Titles link to PubMed; abstracts are not reproduced here. The NLM does not endorse this analysis.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.88

gnomAD pLI

0

gnomAD missense Z

0.06

DepMap mean gene effect

-0.2

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• cell redox homeostasis
• cellular response to oxidative stress
• cellular response to reactive oxygen species
• hydrogen peroxide catabolic process
• maternal placenta development
• mitochondrion organization
• myeloid cell differentiation
• negative regulation of apoptotic process
• negative regulation of kinase activity
• positive regulation of cell population proliferation
• positive regulation of NF-kappaB transcription factor activity
• regulation of mitochondrial membrane potential
• response to hydrogen peroxide
• response to lipopolysaccharide
• response to oxidative stress

Molecular functions

• cysteine-type endopeptidase inhibitor activity involved in apoptotic process
• identical protein binding
• protein kinase binding
• thioredoxin peroxidase activity
• NADH-dependent peroxiredoxin activity

Cellular components

• cytoplasm
• cytosol
• early endosome
• mitochondrial matrix
• mitochondrion
• nucleoplasm
• plasma membrane
• protein-containing complex

Protein domainsUniProt · Pfam · InterPro

• Alkyl hydroperoxide reductase subunit C/ Thiol specific antioxidant
• Thioredoxin domain
• Peroxiredoxin, C-terminal
• Thioredoxin-like superfamily
• Thiol-specific antioxidant peroxiredoxin
• AhpC/TSA family
• C-terminal domain of 1-Cys peroxiredoxin

KeywordsUniProt

• Acetylation
• Antioxidant
• Corneal dystrophy
• Cytoplasm
• Disulfide bond
• Endosome
• Lipoprotein
• Mitochondrion
• Neurodegeneration
• Oxidoreductase
• Palmitate
• Peroxidase
• Phosphoprotein
• Redox-active center
• Transit peptide

InteractionsUniProt · HPA

Protein binding partners of PRDX3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• LRRK2
• MAP3K13
• NEK6
• RPS6KC1
• PRDX2