Seroatlas · Human Serome Atlas

CFAP161

Cilia- and flagella-associated protein 161

Also known as: C15orf26, CF161_HUMAN, FLJ38615

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6P656
Gene: CFAP161
Ensembl: ENSG00000156206
Chromosome: 15
Canonical length: 301 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Predicted to be involved in cilium assembly and flagellated sperm motility. Located in axonemal microtubule. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

301 residues, UniProt reviewed canonical sequence.

>Q6P656|CFAP161
     1  MAQNVYGPGV RIGNWNEDVY LEEELMKDFL EKRDKGKLLI QRSRRLKQNL LRPMQLSVTE
    61  DGYIHYGDKV MLVNPDDPDT EADVFLRGDL SLCMTPDEIQ SHLKDELEVP CGLSAVQAKT
   121  PIGRNTFIIL SVHRDATGQV LRYGQDFCLG ITGGFDNKML YLSSDHRTLL KSSKRSWLQE
   181  VYLTDEVSHV NCWQAAFPDP QLRLEYEGFP VPANAKILIN HCHTNRGLAA HRHLFLSTYF
   241  GKEAEVVAHT YLDSHRVEKP RNHWMLVTGN PRDASSSMLD LPKPPTEDTR AMEQAMGLDT
   301  Q

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CFAP161 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.31
Highest tissue expression: 20 nTPM

Expression across tissuesHPA

Tissue

choroid plexus: 20 nTPM
fallopian tube: 15 nTPM
testis: 6 nTPM
lung: 2.5 nTPM
pituitary gland: 1.6 nTPM
hippocampal formation: 1.5 nTPM

Single-cell type

choroid plexus epithelial cells: 523 nCPM
retinal pigment epithelial cells: 192 nCPM
endometrial secretory cells: 111 nCPM
retinal amacrine cells: 73 nCPM
ependymal cells: 67 nCPM
brain inhibitory neurons: 66 nCPM

Immune cell

total PBMC: 3.4 nTPM
neutrophil: 1.1 nTPM
memory CD8 T-cell: 0.3 nTPM
basophil: 0.2 nTPM
classical monocyte: 0.2 nTPM
intermediate monocyte: 0.2 nTPM

Brain region

choroid plexus: 81 nTPM
cerebellum: 13 nTPM
midbrain: 12 nTPM
spinal cord: 11 nTPM
medulla oblongata: 9.5 nTPM
basal ganglia: 6.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.83
gnomAD pLI: 0.02
DepMap mean gene effect: 0.1
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

Cilia- and flagella-associated protein 161
Cilia- and flagella-associated protein 161-like domain

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CFAP161 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CFAP161 as an antibody target. Whether an autoantibody or antibody against CFAP161 could matter depends on whether native CFAP161 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CFAP161 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CFAP161 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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