Seroatlas · Human Serome Atlas

MRNIP

MRN complex-interacting protein

Also known as: C5orf45, DKFZp686L2452, LOC51149, MGC65027, MGC78537, MRNIP_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6NTE8
Gene: MRNIP
Ensembl: ENSG00000161010
Chromosome: 5
Canonical length: 343 aa
Protein class: Predicted intracellular proteins
Subcellular location: Plasma membrane,Cytosol

OverviewNCBI Gene

Enables chromatin binding activity. Involved in several processes, including mitotic G2 DNA damage checkpoint signaling; positive regulation of protein kinase activity; and regulation of double-strand break repair. Located in Mre11 complex and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

343 residues, UniProt reviewed canonical sequence.

>Q6NTE8|MRNIP
     1  MASLQRSRVL RCCSCRLFQA HQVKKSVKWT CKACGEKQSF LQAYGEGSGA DCRRHVQKLN
    61  LLQGQVSELP LRSLEETVSA SEEENVGHQQ AGNVKQQEKS QPSESRWLKY LEKDSQELEL
   121  EGTGVCFSKQ PSSKMEEPGP RFSQDLPRKR KWSRSTVQPP CSRGVQDSGG SEVAWGPQKG
   181  QAGLTWKVKQ GSSPCLQENS ADCSAGELRG PGKELWSPIQ QVTATSSKWA QFVLPPRKSS
   241  HVDSEQPRSL QRDPRPAGPA QAKQGTPRAQ ASREGLSRPT AAVQLPRATH PVTSGSERPC
   301  GKTSWDARTP WAEGGPLVLE AQNPRPTRLC DLFITGEDFD DDV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MRNIP can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.64
Highest tissue expression: 34 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 34 nTPM
ovary: 19 nTPM
cervix: 18 nTPM
spleen: 18 nTPM
pituitary gland: 17 nTPM
amygdala: 16 nTPM

Single-cell type

ependymal cells: 61 nCPM
brain excitatory neurons: 47 nCPM
choroid plexus epithelial cells: 40 nCPM
brain inhibitory neurons: 38 nCPM
other brain neurons: 37 nCPM
distal convoluted tubule cells: 35 nCPM

Immune cell

naive B-cell: 10 nTPM
memory B-cell: 8 nTPM
naive CD4 T-cell: 6.4 nTPM
plasmacytoid DC: 4.9 nTPM
naive CD8 T-cell: 4.5 nTPM
memory CD4 T-cell: 4 nTPM

Brain region

cerebellum: 12 nTPM
cerebral cortex: 9.7 nTPM
white matter: 8.8 nTPM
choroid plexus: 8.7 nTPM
medulla oblongata: 7.1 nTPM
pons: 7.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.26
gnomAD pLI: 0
DepMap mean gene effect: 0
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

chromatin binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

MRN complex-interacting protein
MRN complex-interacting protein, N-terminal domain
MRN-interacting protein

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of MRNIP in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MRNIP as an antibody target. Whether an autoantibody or antibody against MRNIP could matter depends on whether native MRNIP is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MRNIP is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MRNIP as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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