Seroatlas · Human Serome Atlas

CYREN

Cell cycle regulator of non-homologous end joining

Also known as: C7orf49, CYREN_HUMAN, FLJ22450, FLJ27285, MGC5242, MRI, MRI-2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BWK5
Gene: CYREN
Ensembl: ENSG00000122783
Chromosome: 7
Canonical length: 157 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Predicted to enable molecular adaptor activity. Involved in double-strand break repair via nonhomologous end joining and negative regulation of double-strand break repair via nonhomologous end joining. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

157 residues, UniProt reviewed canonical sequence.

>Q9BWK5|CYREN
     1  METLQSETKT RVLPSWLTAQ VATKNVAPMK APKRMRMAAV PVAAARLPAT RTVYCMNEAE
    61  IVDVALGILI ESRKQEKACE QPALAGADNP EHSPPCSVSP HTSSGSSSEE EDSGKQALAP
   121  GLSPSQRPGG SSSACSRSPE EEEEEDVLKY VREIFFS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CYREN can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.66
Highest tissue expression: 33 nTPM

Expression across tissuesHPA

Tissue

choroid plexus: 33 nTPM
skeletal muscle: 32 nTPM
kidney: 29 nTPM
parathyroid gland: 25 nTPM
tonsil: 22 nTPM
seminal vesicle: 22 nTPM

Single-cell type

cardiomyocytes: 196 nCPM
platelets: 160 nCPM
adipocytes: 107 nCPM
endometrial luminal cells: 104 nCPM
myonuclei: 97 nCPM
endometrial glandular cells: 94 nCPM

Immune cell

basophil: 32 nTPM
myeloid DC: 30 nTPM
eosinophil: 28 nTPM
classical monocyte: 28 nTPM
NK-cell: 27 nTPM
plasmacytoid DC: 26 nTPM

Brain region

medulla oblongata: 33 nTPM
choroid plexus: 33 nTPM
white matter: 31 nTPM
basal ganglia: 25 nTPM
pons: 24 nTPM
cerebellum: 24 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.31
gnomAD pLI: 0.26
DepMap mean gene effect: 0.03
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 12% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

damaged DNA binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

Modulator of retrovirus infection
Modulator of retrovirus infection

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CYREN in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CYREN as an antibody target. Whether an autoantibody or antibody against CYREN could matter depends on whether native CYREN is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CYREN is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CYREN as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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