Seroatlas · Human Serome Atlas

DCLRE1B

5' exonuclease Apollo

Also known as: APOLLO, DCR1B_HUMAN, FLJ12810, FLJ13998, SNM1B

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9H816
Gene: DCLRE1B
Ensembl: ENSG00000118655
Chromosome: 1
Canonical length: 532 aa
Protein class: Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nuclear bodies

OverviewNCBI Gene

DNA interstrand cross-links prevent strand separation, thereby physically blocking transcription, replication, and segregation of DNA. DCLRE1B is one of several evolutionarily conserved genes involved in repair of interstrand cross-links (Dronkert et al., 2000 [PubMed 10848582]).[supplied by OMIM, Mar 2008]

Canonical amino-acid sequenceUniProt

532 residues, UniProt reviewed canonical sequence.

>Q9H816|DCLRE1B
     1  MNGVLIPHTP IAVDFWSLRR AGTARLFFLS HMHSDHTVGL SSTWARPLYC SPITAHLLHR
    61  HLQVSKQWIQ ALEVGESHVL PLDEIGQETM TVTLLDANHC PGSVMFLFEG YFGTILYTGD
   121  FRYTPSMLKE PALTLGKQIH TLYLDNTNCN PALVLPSRQE AAHQIVQLIR KHPQHNIKIG
   181  LYSLGKESLL EQLALEFQTW VVLSPRRLEL VQLLGLADVF TVEEKAGRIH AVDHMEICHS
   241  NMLRWNQTHP TIAILPTSRK IHSSHPDIHV IPYSDHSSYS ELRAFVAALK PCQVVPIVSR
   301  RPCGGFQDSL SPRISVPLIP DSVQQYMSSS SRKPSLLWLL ERRLKRPRTQ GVVFESPEES
   361  ADQSQADRDS KKAKKEKLSP WPADLEKQPS HHPLRIKKQL FPDLYSKEWN KAVPFCESQK
   421  RVTMLTAPLG FSVHLRSTDE EFISQKTREE IGLGSPLVPM GDDDGGPEAT GNQSAWMGHG
   481  SPLSHSSKGT PLLATEFRGL ALKYLLTPVN FFQAGYSSRR FDQQVEKYHK PC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DCLRE1B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.41
Highest tissue expression: 5.5 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 5.5 nTPM
thymus: 4.5 nTPM
cerebellum: 3.9 nTPM
lymph node: 3.8 nTPM
spleen: 3.7 nTPM
appendix: 3.5 nTPM

Single-cell type

cardiomyocytes: 45 nCPM
erythrocyte progenitors: 21 nCPM
adipocytes: 14 nCPM
monocyte progenitors: 13 nCPM
differentiating spermatogonia: 12 nCPM
extravillous trophoblasts: 12 nCPM

Immune cell

NK-cell: 5.8 nTPM
classical monocyte: 4.1 nTPM
intermediate monocyte: 3.4 nTPM
MAIT T-cell: 2.5 nTPM
myeloid DC: 2.5 nTPM
total PBMC: 2.4 nTPM

Brain region

cerebellum: 6.5 nTPM
white matter: 4 nTPM
midbrain: 3.7 nTPM
thalamus: 3.5 nTPM
hypothalamus: 3.4 nTPM
basal ganglia: 3.3 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about DCLRE1B.

Disease | AllUniProt

Conditions DCLRE1B is implicated in, by any mechanism.

Dyskeratosis congenita, autosomal recessive, 8 (DKCB8) MIM:620133

Disease | GeneticClinVar

5 pathogenic / likely-pathogenic of 173 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Dyskeratosis congenita, autosomal recessive 8
Fanconi anemia complementation group C

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.47
gnomAD pLI: 0.54
gnomAD missense Z: 0.55
DepMap mean gene effect: -0.72
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of DCLRE1B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DCLRE1B as an antibody target. Whether an autoantibody or antibody against DCLRE1B could matter depends on whether native DCLRE1B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DCLRE1B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label DCLRE1B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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