Seroatlas · Human Serome Atlas

STK38L

Serine/threonine-protein kinase 38-like

Also known as: KIAA0965, NDR2, ST38L_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9Y2H1
Gene
STK38L
Ensembl
ENSG00000211455
Chromosome
12
Canonical length
464 aa
Protein class
Enzymes, Predicted intracellular proteins
Subcellular location
Cytosol

OverviewNCBI Gene

Enables ATP binding activity; magnesium ion binding activity; and protein serine/threonine kinase activity. Involved in intracellular signal transduction and negative regulation of autophagy. Acts upstream of or within protein phosphorylation. Located in cytosol. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

464 residues, UniProt reviewed canonical sequence.

>Q9Y2H1|STK38L
     1  MAMTAGTTTT FPMSNHTRER VTVAKLTLEN FYSNLILQHE ERETRQKKLE VAMEEEGLAD
    61  EEKKLRRSQH ARKETEFLRL KRTRLGLDDF ESLKVIGRGA FGEVRLVQKK DTGHIYAMKI
   121  LRKSDMLEKE QVAHIRAERD ILVEADGAWV VKMFYSFQDK RNLYLIMEFL PGGDMMTLLM
   181  KKDTLTEEET QFYISETVLA IDAIHQLGFI HRDIKPDNLL LDAKGHVKLS DFGLCTGLKK
   241  AHRTEFYRNL THNPPSDFSF QNMNSKRKAE TWKKNRRQLA YSTVGTPDYI APEVFMQTGY
   301  NKLCDWWSLG VIMYEMLIGY PPFCSETPQE TYRKVMNWKE TLVFPPEVPI SEKAKDLILR
   361  FCIDSENRIG NSGVEEIKGH PFFEGVDWEH IRERPAAIPI EIKSIDDTSN FDDFPESDIL
   421  QPVPNTTEPD YKSKDWVFLN YTYKRFEGLT QRGSIPTYMK AGKL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against STK38L can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.28
Highest tissue expression
80 nTPM

Expression across tissuesHPA

Tissue

  • blood vessel: 80 nTPM
  • heart muscle: 42 nTPM
  • smooth muscle: 31 nTPM
  • colon: 28 nTPM
  • endometrium: 25 nTPM
  • parathyroid gland: 25 nTPM

Single-cell type

  • neutrophils: 655 nCPM
  • esophageal apical cells: 397 nCPM
  • neutrophil progenitors: 309 nCPM
  • ocular epithelial cells: 228 nCPM
  • adipocytes: 209 nCPM
  • monocytes: 195 nCPM

Immune cell

  • neutrophil: 81 nTPM
  • eosinophil: 61 nTPM
  • myeloid DC: 50 nTPM
  • classical monocyte: 33 nTPM
  • intermediate monocyte: 29 nTPM
  • non-classical monocyte: 23 nTPM

Brain region

  • thalamus: 33 nTPM
  • cerebral cortex: 33 nTPM
  • hypothalamus: 31 nTPM
  • medulla oblongata: 30 nTPM
  • spinal cord: 29 nTPM
  • midbrain: 29 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.35
gnomAD pLI
0.93
gnomAD missense Z
2.94
DepMap mean gene effect
0.06
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of STK38L in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads STK38L as an antibody target. Whether an autoantibody or antibody against STK38L could matter depends on whether native STK38L is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

STK38L is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label STK38L as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/STK38L. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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