Seroatlas · Human Serome Atlas

SRRM4

Serine/arginine repetitive matrix protein 4

Also known as: KIAA1853, nSR100, SRRM4_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
A7MD48
Gene
SRRM4
Ensembl
ENSG00000139767
Chromosome
12
Canonical length
611 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

SRRM4 promotes alternative splicing and inclusion of neural-specific exons in target mRNAs (Calarco et al., 2009 [PubMed 19737518]).[supplied by OMIM, Oct 2009]

Canonical amino-acid sequenceUniProt

611 residues, UniProt reviewed canonical sequence.

>A7MD48|SRRM4
     1  MASVQQGEKQ LFEKFWRGTF KAVATPRPES IIVASITARK PLPRTEPQNN PVVPAQDGPS
    61  EKLGQHLATE PLGTNSWERD KTCRELGATR GHSASHDKDL TPPPSSRGKK KKKKSTRKKR
   121  RRSSSYSPSP VKKKKKKSSK KHKRRRSFSK KRRHSSSSPK SKRRDEKRHK KQSRSRPRKS
   181  HRHRHHRCPS RSQSSESRPS SCESRHRGRS PEEGQKSRRR HSRRCSKTLC KDSPEAQSSR
   241  PPSQPLQMLG YLSARGVITG SGSAADLFTK TASPLTTSRG RSQEYDSGND TSSPPSTQTS
   301  SARSRGQEKG SPSGGLSKSR ELNSGNTSDS GNSFTTSSPQ NKGAMLENLS PTSRGRESRG
   361  FQSPCLECAE VKKSSLVPST ARSSPMKGCS RSSSYASTRS SSHSSRSPNP RASPRYTQSR
   421  STSSEKRSYS RSPSYSSKSG KRSPPSRSSR SRRSPSYSRY SPSRERDPKY SEKDSQQRER
   481  ERARRRRRSY SPMRKRRRDS PSHLEARRIT SARKRPIPYY RPSPSSSGSL SSTSSWYSSS
   541  SSRSASRSYS RSRSRSRSRR RSRTRTSSSS SSRSPSPGSR SRSRSRSRSR SRSRSQSRSY
   601  SSADSYSSTR R

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SRRM4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.71
Highest tissue expression
44 nTPM

Expression across tissuesHPA

Tissue

  • cerebellum: 44 nTPM
  • retina: 27 nTPM
  • cerebral cortex: 14 nTPM
  • hypothalamus: 4.9 nTPM
  • hippocampal formation: 4.3 nTPM
  • amygdala: 4.1 nTPM

Single-cell type

  • cone photoreceptor cells: 1,052 nCPM
  • retinal amacrine cells: 957 nCPM
  • rod photoreceptor cells: 775 nCPM
  • retinal bipolar cells: 700 nCPM
  • brain excitatory neurons: 330 nCPM
  • retinal ganglion cells: 232 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • cerebral cortex: 66 nTPM
  • cerebellum: 60 nTPM
  • basal ganglia: 44 nTPM
  • white matter: 40 nTPM
  • thalamus: 25 nTPM
  • hippocampal formation: 23 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.41
gnomAD pLI
0.46
gnomAD missense Z
1.39
DepMap mean gene effect
0.06
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SRRM4 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SRRM4 as an antibody target. Whether an autoantibody or antibody against SRRM4 could matter depends on whether native SRRM4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SRRM4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SRRM4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SRRM4. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...