Seroatlas · Human Serome Atlas

JADE3

Protein Jade-3

Also known as: JADE-3, JADE3_HUMAN, KIAA0215, PHF16

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q92613
Gene: JADE3
Ensembl: ENSG00000102221
Chromosome: X
Canonical length: 823 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nucleoli

OverviewNCBI Gene

This gene encodes a member of a family of large proteins containing PHD (plant homeo domain)-type zinc fingers. The encoded protein may be associated in a nuclear complex that functions in histone H4 acetylation. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Aug 2013]

Canonical amino-acid sequenceUniProt

823 residues, UniProt reviewed canonical sequence.

>Q92613|JADE3
     1  MKRHRPVSSS DSSDESPSTS FTSGSMYRIK SKIPNEHKKP AEVFRKDLIS AMKLPDSHHI
    61  NPDSYYLFAD TWKEEWEKGV QVPASPDTVP QPSLRIIAEK VKDVLFIRPR KYIHCSSPDT
   121  TEPGYINIME LAASVCRYDL DDMDIFWLQE LNEDLAEMGC GPVDENLMEK TVEVLERHCH
   181  ENMNHAIETE EGLGIEYDED VICDVCRSPD SEEGNDMVFC DKCNVCVHQA CYGILKVPEG
   241  SWLCRSCVLG IYPQCVLCPK KGGALKTTKT GTKWAHVSCA LWIPEVSIAC PERMEPITKI
   301  SHIPPSRWAL VCNLCKLKTG ACIQCSIKSC ITAFHVTCAF EHGLEMKTIL DEGDEVKFKS
   361  YCLKHSQNRQ KLGEAEYPHH RAKEQSQAKS EKTSLRAQKL RELEEEFYSL VRVEDVAAEL
   421  GMPTLAVDFI YNYWKLKRKS NFNKPLFPPK EDEENGLVQP KEESIHTRMR MFMHLRQDLE
   481  RVRNLCYMIS RREKLKLSHN KIQEQIFGLQ VQLLNQEIDA GLPLTNALEN SLFYPPPRIT
   541  LKLKMPKSTP EDHRNSSTET DQQPHSPDSS SSVHSIRNMQ VPQESLEMRT KSYPRYPLES
   601  KNNRLLASLS HSRSEAKESS PAWRTPSSEC YHGQSLGKPL VLQAALHGQS SIGNGKSQPN
   661  SKFAKSNGLE GSWSGNVTQK DSSSEMFCDQ EPVFSPHLVS QGSFRKSTVE HFSRSFKETT
   721  NRWVKNTEDL QCYVKPTKNM SPKEQFWGRQ VLRRSAGRAP YQENDGYCPD LELSDSEAES
   781  DGNKEKVRVR KDSSDRENPP HDSRRDCHGK SKTHPLSHSS MQR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against JADE3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.53
Highest tissue expression: 15 nTPM

Expression across tissuesHPA

Tissue

epididymis: 15 nTPM
placenta: 14 nTPM
testis: 11 nTPM
adrenal gland: 10 nTPM
pancreas: 7.9 nTPM
spinal cord: 7.2 nTPM

Single-cell type

adrenal cortex cells: 200 nCPM
early primary spermatocytes: 151 nCPM
b-cells: 146 nCPM
sertoli cells: 81 nCPM
renal collecting duct intercalated cells: 77 nCPM
epididymal clear cells: 71 nCPM

Immune cell

memory B-cell: 1.8 nTPM
naive B-cell: 1.3 nTPM
plasmacytoid DC: 0.7 nTPM
total PBMC: 0.2 nTPM
NK-cell: 0.1 nTPM
non-classical monocyte: 0.1 nTPM

Brain region

white matter: 17 nTPM
medulla oblongata: 13 nTPM
pons: 11 nTPM
thalamus: 9.6 nTPM
cerebellum: 9.5 nTPM
spinal cord: 9.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.12
gnomAD pLI: 1
gnomAD missense Z: 1.9
DepMap mean gene effect: -0.14
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

zinc ion binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of JADE3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

KAT7

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads JADE3 as an antibody target. Whether an autoantibody or antibody against JADE3 could matter depends on whether native JADE3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

JADE3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label JADE3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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