Seroatlas · Human Serome Atlas

BRPF1

Peregrin

Also known as: BR140, BRPF1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P55201
Gene: BRPF1
Ensembl: ENSG00000156983
Chromosome: 3
Canonical length: 1214 aa
Protein class: Disease related genes, Human disease related genes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins
Subcellular location: Plasma membrane,Cytosol

OverviewNCBI Gene

This gene encodes a bromodomain, PHD finger and chromo/Tudor-related Pro-Trp-Trp-Pro (PWWP) domain containing protein. The encoded protein is a component of the MOZ/MORF histone acetyltransferase complexes which function as a transcriptional regulators. This protein binds to the catalytic MYST domains of the MOZ and MORF proteins and may play a role in stimulating acetyltransferase and transcriptional activity of the complex. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]

Canonical amino-acid sequenceUniProt

1214 residues, UniProt reviewed canonical sequence.

>P55201|BRPF1
     1  MGVDFDVKTF CHNLRATKPP YECPVETCRK VYKSYSGIEY HLYHYDHDNP PPPQQTPLRK
    61  HKKKGRQSRP ANKQSPSPSE VSQSPGREVM SYAQAQRMVE VDLHGRVHRI SIFDNLDVVS
   121  EDEEAPEEAP ENGSNKENTE TPAATPKSGK HKNKEKRKDS NHHHHHNVSA STTPKLPEVV
   181  YRELEQDTPD APPRPTSYYR YIEKSAEELD EEVEYDMDEE DYIWLDIMNE RRKTEGVSPI
   241  PQEIFEYLMD RLEKESYFES HNKGDPNALV DEDAVCCICN DGECQNSNVI LFCDMCNLAV
   301  HQECYGVPYI PEGQWLCRRC LQSPSRAVDC ALCPNKGGAF KQTDDGRWAH VVCALWIPEV
   361  CFANTVFLEP IDSIEHIPPA RWKLTCYICK QRGSGACIQC HKANCYTAFH VTCAQQAGLY
   421  MKMEPVRETG ANGTSFSVRK TAYCDIHTPP GSARRLPALS HSEGEEDEDE EEDEGKGWSS
   481  EKVKKAKAKS RIKMKKARKI LAEKRAAAPV VSVPCIPPHR LSKITNRLTI QRKSQFMQRL
   541  HSYWTLKRQS RNGVPLLRRL QTHLQSQRNC DQVGRDSEDK NWALKEQLKS WQRLRHDLER
   601  ARLLVELIRK REKLKRETIK VQQIAMEMQL TPFLILLRKT LEQLQEKDTG NIFSEPVPLS
   661  EVPDYLDHIK KPMDFFTMKQ NLEAYRYLNF DDFEEDFNLI VSNCLKYNAK DTIFYRAAVR
   721  LREQGGAVLR QARRQAEKMG IDFETGMHIP HSLAGDEATH HTEDAAEEER LVLLENQKHL
   781  PVEEQLKLLL ERLDEVNASK QSVGRSRRAK MIKKEMTALR RKLAHQRETG RDGPERHGPS
   841  SRGSLTPHPA ACDKDGQTDS AAEESSSQET SKGLGPNMSS TPAHEVGRRT SVLFSKKNPK
   901  TAGPPKRPGR PPKNRESQMT PSHGGSPVGP PQLPIMSSLR QRKRGRSPRP SSSSDSDSDK
   961  STEDPPMDLP ANGFSGGNQP VKKSFLVYRN DCSLPRSSSD SESSSSSSSS AASDRTSTTP
  1021  SKQGRGKPSF SRGTFPEDSS EDTSGTENEA YSVGTGRGVG HSMVRKSLGR GAGWLSEDED
  1081  SPLDALDLVW AKCRGYPSYP ALIIDPKMPR EGMFHHGVPI PVPPLEVLKL GEQMTQEARE
  1141  HLYLVLFFDN KRTWQWLPRT KLVPLGVNQD LDKEKMLEGR KSNIRKSVQI AYHRALQHRS
  1201  KVQGEQSSET SDSD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against BRPF1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.47
Highest tissue expression: 22 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 22 nTPM
thymus: 12 nTPM
testis: 9.6 nTPM
lymph node: 8.5 nTPM
skin: 7.8 nTPM
parathyroid gland: 7.7 nTPM

Single-cell type

megakaryocyte progenitors: 18 nCPM
early primary spermatocytes: 17 nCPM
neutrophil progenitors: 15 nCPM
differentiating spermatogonia: 15 nCPM
thymic myoid cells: 15 nCPM
erythrocyte progenitors: 15 nCPM

Immune cell

NK-cell: 5.2 nTPM
plasmacytoid DC: 3.6 nTPM
MAIT T-cell: 2.7 nTPM
gdT-cell: 2.3 nTPM
naive CD4 T-cell: 2.1 nTPM
naive CD8 T-cell: 2.1 nTPM

Brain region

cerebellum: 16 nTPM
cerebral cortex: 13 nTPM
basal ganglia: 13 nTPM
hippocampal formation: 12 nTPM
thalamus: 11 nTPM
white matter: 11 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about BRPF1.

Disease | AllUniProt

Conditions BRPF1 is implicated in, by any mechanism.

Intellectual developmental disorder with dysmorphic facies and ptosis (IDDDFP) MIM:617333

Disease | GeneticClinVar

97 pathogenic / likely-pathogenic of 505 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Intellectual developmental disorder with dysmorphic facies and ptosis
Inborn genetic diseases
BRPF1-related disorder
Intellectual disability
Neurodevelopmental disorder

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.18
gnomAD pLI: 1
gnomAD missense Z: 3.83
DepMap mean gene effect: -0.23
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of BRPF1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads BRPF1 as an antibody target. Whether an autoantibody or antibody against BRPF1 could matter depends on whether native BRPF1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

BRPF1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label BRPF1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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