ING family
IPR028651
Definition
This family of chromatin modification proteins are involved in the regulation of cell cycle progression, apoptosis, and DNA repair. Members are found in yeast, animals and plants. They share significant sequence in their C-terminal regions containing PHD finger domains, which have been implicated in chromatin-mediated transcriptional regulation PMID:10805724. The family includes proteins YNG1, YNG2 and Pho23 from Saccharomyces cerevisiae [[cite:PMID:10805724], [cite:PMID:12672825]], png1 and png2 from Schizosaccharomyces pombe PMID:10805724, inhibitor of growth proteins ING1-5 from mammals PMID:15356280, and Arabidopsis homologues ING1 (At3g24010) and ING2 (At1g54390) PMID:19154204.
5 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
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