Seroatlas · Human Serome Atlas

HSPBP1

Hsp70-binding protein 1

Also known as: FES1, HPBP1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9NZL4
Gene
HSPBP1
Ensembl
ENSG00000133265
Chromosome
19
Canonical length
359 aa
Protein class
Predicted intracellular proteins
Subcellular location
Vesicles,Centrosome,Cytosol

OverviewNCBI Gene

Enables molecular sequestering activity and ubiquitin protein ligase binding activity. Involved in positive regulation of proteasomal ubiquitin-dependent protein catabolic process and positive regulation of protein ubiquitination. Is active in extracellular space. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

359 residues, UniProt reviewed canonical sequence.

>Q9NZL4|HSPBP1
     1  MSDEGSRGSR LPLALPPASQ GCSSGGGGGG SSAGGSGNSR PPRNLQGLLQ MAITAGSEEP
    61  DPPPEPMSEE RRQWLQEAMS AAFRGQREEV EQMKSCLRVL SQPMPPTAGE AEQAADQQER
   121  EGALELLADL CENMDNAADF CQLSGMHLLV GRYLEAGAAG LRWRAAQLIG TCSQNVAAIQ
   181  EQVLGLGALR KLLRLLDRDA CDTVRVKALF AISCLVREQE AGLLQFLRLD GFSVLMRAMQ
   241  QQVQKLKVKS AFLLQNLLVG HPEHKGTLCS MGMVQQLVAL VRTEHSPFHE HVLGALCSLV
   301  TDFPQGVREC REPELGLEEL LRHRCQLLQQ HEEYQEELEF CEKLLQTCFS SPADDSMDR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against HSPBP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Secreted
Secreted
Yes
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.35
Highest tissue expression
118 nTPM

Expression across tissuesHPA

Tissue

  • basal ganglia: 118 nTPM
  • cerebral cortex: 79 nTPM
  • hippocampal formation: 71 nTPM
  • amygdala: 65 nTPM
  • hypothalamus: 55 nTPM
  • heart muscle: 45 nTPM

Single-cell type

  • respiratory ciliated cells: 145 nCPM
  • epididymal efferent duct ciliated cells: 137 nCPM
  • fallopian tube ciliated cells: 110 nCPM
  • esophageal basal cells: 91 nCPM
  • esophageal suprabasal cells: 84 nCPM
  • endometrial ciliated cells: 84 nCPM

Immune cell

  • naive B-cell: 65 nTPM
  • memory B-cell: 54 nTPM
  • myeloid DC: 53 nTPM
  • intermediate monocyte: 45 nTPM
  • memory CD8 T-cell: 45 nTPM
  • NK-cell: 44 nTPM

Brain region

  • basal ganglia: 70 nTPM
  • cerebral cortex: 61 nTPM
  • midbrain: 53 nTPM
  • hippocampal formation: 53 nTPM
  • amygdala: 52 nTPM
  • cerebellum: 52 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.65
gnomAD pLI
0.06
gnomAD missense Z
1.04
DepMap mean gene effect
0.16
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of HSPBP1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads HSPBP1 as an antibody target. Whether an autoantibody or antibody against HSPBP1 could matter depends on whether native HSPBP1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

HSPBP1 is annotated as secreted, so native HSPBP1 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label HSPBP1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/HSPBP1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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