Seroatlas · Human Serome Atlas

SHCBP1L

Testicular spindle-associated protein SHCBP1L

Also known as: C1orf14, SHP1L_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9BZQ2
Gene
SHCBP1L
Ensembl
ENSG00000157060
Chromosome
1
Canonical length
653 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

This gene encodes a Src homology 2 domain-binding protein 1-like protein. The encoded protein interacts with heat shock 70 kDa protein 2 and may be involved in maintaining spindle integrity during meiosis. This gene is located in region of chromoso0me 1 encompassing a prostate cancer susceptibility locus. [provided by RefSeq, Sep 2016]

Canonical amino-acid sequenceUniProt

653 residues, UniProt reviewed canonical sequence.

>Q9BZQ2|SHCBP1L
     1  MASGSKASVP ADSFRTISPD RRGEKSASAV SGDTAAATTL KGTAIPVRSV VASPRPVKGK
    61  AGRETARLRL QRLPAAQAED TGEAAAAAAE EPLLPVPEDE EEAQPLPPVC VSRMRGMWRD
   121  EKVSLYCDEV LQDCKAEDAD EVMGKYLSEK LKLKDKWLGV WKTNPSVFFV KYEEASIPFV
   181  GILVEVTCEP YQDSSSRFKV TVSVAEPFSS NIANIPRDLV DEILEELEHS VPLLEVYPVE
   241  GQDTDIHVIA LALEVVRFFY DFLWRDWDDE ESCENYTALI EERINLWCDI QDGTIPGPIA
   301  QRFKKTLEKY KNKRVELIEY QSNIKEDPSA AEAVECWKKY YEIVMLCGLL KMWEDLRLRV
   361  HGPFFPRILR RRKGKREFGK TITHIVAKMM TTEMIKDLSS DTLLQQHGDL DLALDNCYSG
   421  DTVIIFPGEY QAANLALLTD DIIIKGVGKR EEIMITSEPS RDSFVVSKAD NVKLMHLSLI
   481  QQGTVDGIVV VESGHMTLEN CILKCEGTGV CVLTGAALTI TDSEITGAQG AGVELYPGSI
   541  AILERNEIHH CNNLRTSNSS KSTLGGVNMK VLPAPKLKMT NNHIYSNKGY GVSILQPMEQ
   601  FFIVAEEALN KRASSGDKKD DKMLFKVMQN LNLEMNNNKI EANVKGDIRI VTS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SHCBP1L can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.32
Highest tissue expression
107 nTPM

Expression across tissuesHPA

Tissue

  • testis: 107 nTPM
  • adipose tissue: 0 nTPM
  • adrenal gland: 0 nTPM
  • amygdala: 0 nTPM
  • appendix: 0 nTPM
  • basal ganglia: 0 nTPM

Single-cell type

  • late primary spermatocytes: 1,240 nCPM
  • early spermatids: 654 nCPM
  • early primary spermatocytes: 511 nCPM
  • late spermatids: 60 nCPM
  • differentiating spermatogonia: 14 nCPM
  • sertoli cells: 7.1 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • amygdala: 0 nTPM
  • basal ganglia: 0 nTPM
  • cerebellum: 0 nTPM
  • cerebral cortex: 0 nTPM
  • choroid plexus: 0 nTPM
  • hippocampal formation: 0 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.37
gnomAD pLI
0
gnomAD missense Z
0.03
DepMap mean gene effect
-0.07
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SHCBP1L in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SHCBP1L as an antibody target. Whether an autoantibody or antibody against SHCBP1L could matter depends on whether native SHCBP1L is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SHCBP1L is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SHCBP1L as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SHCBP1L. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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