Seroatlas · Human Serome Atlas

HOMER1

Homer protein homolog 1

Also known as: HOME1_HUMAN, HOMER-1B, SYN47, Ves-1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q86YM7
Gene: HOMER1
Ensembl: ENSG00000152413
Chromosome: 5
Canonical length: 354 aa
Protein class: Predicted intracellular proteins
Subcellular location: Cytosol

OverviewNCBI Gene

This gene encodes a member of the homer family of dendritic proteins. Members of this family regulate group 1 metabotrophic glutamate receptor function. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

354 residues, UniProt reviewed canonical sequence.

>Q86YM7|HOMER1
     1  MGEQPIFSTR AHVFQIDPNT KKNWVPTSKH AVTVSYFYDS TRNVYRIISL DGSKAIINST
    61  ITPNMTFTKT SQKFGQWADS RANTVYGLGF SSEHHLSKFA EKFQEFKEAA RLAKEKSQEK
   121  MELTSTPSQE SAGGDLQSPL TPESINGTDD ERTPDVTQNS EPRAEPTQNA LPFSHSSAIS
   181  KHWEAELATL KGNNAKLTAA LLESTANVKQ WKQQLAAYQE EAERLHKRVT ELECVSSQAN
   241  AVHTHKTELN QTIQELEETL KLKEEEIERL KQEIDNAREL QEQRDSLTQK LQEVEIRNKD
   301  LEGQLSDLEQ RLEKSQNEQE AFRNNLKTLL EILDGKIFEL TELRDNLAKL LECS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against HOMER1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.42
Highest tissue expression: 32 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 32 nTPM
cerebral cortex: 28 nTPM
heart muscle: 19 nTPM
thyroid gland: 14 nTPM
tongue: 12 nTPM
basal ganglia: 8.4 nTPM

Single-cell type

epicardial cells: 935 nCPM
salivary myoepithelial cells: 596 nCPM
granulosa cells: 340 nCPM
lactotrophs: 327 nCPM
myonuclei: 316 nCPM
salivary basal cells: 315 nCPM

Immune cell

gdT-cell: 0.4 nTPM
memory B-cell: 0.4 nTPM
naive B-cell: 0.3 nTPM
naive CD8 T-cell: 0.3 nTPM
MAIT T-cell: 0.2 nTPM
memory CD4 T-cell: 0.1 nTPM

Brain region

cerebral cortex: 117 nTPM
hippocampal formation: 93 nTPM
white matter: 90 nTPM
basal ganglia: 87 nTPM
cerebellum: 81 nTPM
thalamus: 74 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.14
gnomAD pLI: 1
gnomAD missense Z: 2.43
DepMap mean gene effect: 0.11
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of HOMER1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads HOMER1 as an antibody target. Whether an autoantibody or antibody against HOMER1 could matter depends on whether native HOMER1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

HOMER1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label HOMER1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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