Seroatlas · Human Serome Atlas

FRYL

Protein furry homolog-like

Also known as: AF4p12, DKFZp686E205, FRYL_HUMAN, KIAA0826, MOR2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O94915
Gene
FRYL
Ensembl
ENSG00000075539
Chromosome
4
Canonical length
3013 aa
Protein class
Disease related genes, Predicted intracellular proteins
Subcellular location
Microtubules,Cytokinetic bridge,Cytosol

OverviewNCBI Gene

Predicted to be involved in cell morphogenesis and neuron projection development. Predicted to be active in cell cortex and site of polarized growth. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

3013 residues, UniProt reviewed canonical sequence.

>O94915|FRYL
     1  MSNITIDPDV KPGEYVIKSL FAEFAVQAEK KIEVVMAEPL EKLLSRSLQR GEDLQFDQLI
    61  SSMSSVAEHC LPSLLRTLFD WYRRQNGTED ESYEYRPRSS TKSKGDEQQR ERDYLLERRD
   121  LAVDFIFCLV LVEVLKQIPV HPVPDPLVHE VLNLAFKHFK HKEGYSGTNT GNVHIIADLY
   181  AEVIGVLAQS KFQAVRKKFV TELKELRQKE QSPHVVQSVI SLIMGMKFFR VKMYPVEDFE
   241  ASFQFMQECA QYFLEVKDKD IKHALAGLFV EILIPVAAAV KNEVNVPCLK NFVEMLYQTT
   301  FELSSRKKHS LALYPLITCL LCVSQKQFFL NNWHIFLQNC LSHLKNKDPK MSRVALESLY
   361  RLLWVYVIRI KCESNTVTQS RLMSIVSALF PKGSRSVVPR DTPLNIFVKI IQFIAQERLD
   421  FAMKEIIFDL LSVGKSTKTF TINPERMNIG LRVFLVIADS LQQKDGEPPM PTTGVILPSG
   481  NTLRVKKIFL NKTLTDEEAK VIGMSVYYPQ VRKALDSILR HLDKEVGRPM CMTSVQMSNK
   541  EPEDMITGER KPKIDLFRTC IAAIPRLIPD GMSRTDLIEL LARLTIHMDE ELRALAFNTL
   601  QALMLDFPDW REDVLSGFVY FIVREVTDVH PTLLDNAVKM LVQLINQWKQ AAQMHNKNQD
   661  TQHGVANGAS HPPPLERSPY SNVFHVVEGF ALVILCSSRP ATRRLAVSVL REIRALFALL
   721  EIPKGDDELA IDVMDRLSPS ILESFIHLTG ADQTTLLYCP SSIDLQTLAE WNSSPISHQF
   781  DVISPSHIWI FAHVTQGQDP WIISLSSFLK QENLPKHCST AVSYAWMFAY TRLQLLSPQV
   841  DINSPINAKK VNTTTSSDSY IGLWRNYLIL CCSAATSSSS TSAGSVRCSP PETLASTPDS
   901  GYSIDSKIIG IPSPSSLFKH IVPMMRSESM EITESLVLGL GRTNPGAFRE LIEELHPIIK
   961  EALERRPENM KRRRRRDILR VQLVRIFELL ADAGVISHSA SGGLDNETHF LNNTLLEYVD
  1021  LTRQLLEAEN EKDSDTLKDI RCHFSALVAN IIQNVPVHQR RSIFPQQSLR HSLFMLFSHW
  1081  AGPFSIMFTP LDRYSDRNMQ INRHQYCALK AMSAVLCCGP VADNVGLSSD GYLYKWLDNI
  1141  LDSLDKKVHQ LGCEAVTLLL ELNPDQSNLM YWAVDRCYTG SGRVAAGCFK AIANVFQNRD
  1201  YQCDTVMLLN LILFKAADSS RSIYEVAMQL LQILEPKMFR YAHKLEVQRT DGVLSQLSPL
  1261  PHLYSVSYYQ LSEELARAYP ELTLAIFSEI SQRIQTAHPA GRQVMLHYLL PWMNNIELVD
  1321  LKPLPTARRH DEDEDDSLKD RELMVTSRRW LRGEGWGSPQ ATAMVLNNLM YMTAKYGDEL
  1381  AWSEVENVWT TLADGWPKNL KIILHFLISI CGVNSEPSLL PYVKKVIVYL GRDKTMQLLE
  1441  ELVSELQLTD PVSSGVTHMD NPPYYRITSS YKIPSVTSGT TSSSNTMVAP TDGNPDNKPI
  1501  KENIEESYVH LDIYSGLNSH LNRQHHRLES RYSSSSGGSY EEEKSDSMPL YSNWRLKVME
  1561  HNQGEPLPFP PAGGCWSPLV DYVPETSSPG LPLHRCNIAV ILLTDLIIDH SVKVEWGSYL
  1621  HLLLHAIFIG FDHCHPEVYE HCKRLLLHLL IVMGPNSNIR TVASVLLRNK EFNEPRVLTV
  1681  KQVAHLDYNF TAGINDFIPD YQPSPMTDSG LSSSSTSSSI SLGNNSAAIS HLHTTILNEV
  1741  DISVEQDGKV KTLMEFITSR KRGPLWNHED VSAKNPSIKS AEQLTTFLKH VVSVFKQSSS
  1801  EGIHLEHHLS EVALQTALSC SSRHYAGRSF QIFRALKQPL TATTLSDVLS RLVETVGDPG
  1861  EDAQGFVIEL LLTLESAIDT LAETMKHYDL LSALSQTSYH DPIMGNKYAA NRKSTGQLNL
  1921  STSPINSSSY LGYNSNARSN SLRLSLIGDR RGDRRRSNTL DIMDGRINHS SSLARTRSLS
  1981  SLREKGMYDV QSTTEPTNLM ATIFWIAASL LESDYEYEYL LALRLLNKLL IHLPLDKSES
  2041  REKIENVQSK LKWTNFPGLQ QLFLKGFTSA STQEMTVHLL SKLISVSKHT LVDPSQLSGF
  2101  PLNILCLLPH LIQHFDSPTQ FCKETASRIA KVCAEEKCPT LVNLAHMMSL YSTHTYSRDC
  2161  SNWINVVCRY LHDSFSDTTF NLVTYLAELL EKGLSSMQQS LLQIIYSLLS HIDLSAAPAK
  2221  QFNLEIIKII GKYVQSPYWK EALNILKLVV SRSASLVVPS DIPKTYGGDT GSPEISFTKI
  2281  FNNVSKELPG KTLDFHFDIS ETPIIGNKYG DQHSAAGRNG KPKVIAVTRS TSSTSSGSNS
  2341  NALVPVSWKR PQLSQRRTRE KLMNVLSLCG PESGLPKNPS VVFSSNEDLE VGDQQTSLIS
  2401  TTEDINQEEE VAVEDNSSEQ QFGVFKDFDF LDVELEDAEG ESMDNFNWGV RRRSLDSIDK
  2461  GDTPSLQEYQ CSSSTPSLNL TNQEDTDESS EEEAALTASQ ILSRTQMLNS DSATDETIPD
  2521  HPDLLLQSED STGSITTEEV LQIRDETPTL EASLDNANSR LPEDTTSVLK EEHVTTFEDE
  2581  GSYIIQEQQE SLVCQGILDL EETEMPEPLA PESYPESVCE EDVTLALKEL DERCEEEEAD
  2641  FSGLSSQDEE EQDGFPEVQT SPLPSPFLSA IIAAFQPVAY DDEEEAWRCH VNQMLSDTDG
  2701  SSAVFTFHVF SRLFQTIQRK FGEITNEAVS FLGDSLQRIG TKFKSSLEVM MLCSECPTVF
  2761  VDAETLMSCG LLETLKFGVL ELQEHLDTYN VKREAAEQWL DDCKRTFGAK EDMYRINTDA
  2821  QQMEILAELE LCRRLYKLHF QLLLLFQAYC KLINQVNTIK NEAEVINMSE ELAQLESILK
  2881  EAESASENEE IDISKAAQTT IETAIHSLIE TLKNKEFISA VAQVKAFRSL WPSDIFGSCE
  2941  DDPVQTLLHI YFHHQTLGQT GSFAVIGSNL DMSEANYKLM ELNLEIRESL RMVQSYQLLA
  3001  QAKPMGNMVS TGF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FRYL can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0
Highest tissue expression
30 nTPM

Expression across tissuesHPA

Tissue

  • colon: 30 nTPM
  • rectum: 29 nTPM
  • retina: 25 nTPM
  • parathyroid gland: 14 nTPM
  • bone marrow: 13 nTPM
  • spinal cord: 13 nTPM

Single-cell type

  • oligodendrocytes: 1,417 nCPM
  • goblet cells: 849 nCPM
  • colonocytes: 515 nCPM
  • rod photoreceptor cells: 509 nCPM
  • vascular endothelial cells: 424 nCPM
  • neutrophil progenitors: 419 nCPM

Immune cell

  • basophil: 13 nTPM
  • neutrophil: 2.7 nTPM
  • NK-cell: 2.3 nTPM
  • naive CD4 T-cell: 1.8 nTPM
  • eosinophil: 1.7 nTPM
  • gdT-cell: 1.7 nTPM

Brain region

  • white matter: 197 nTPM
  • basal ganglia: 123 nTPM
  • medulla oblongata: 108 nTPM
  • pons: 91 nTPM
  • cerebellum: 91 nTPM
  • cerebral cortex: 90 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about FRYL.

Disease | AllUniProt

Conditions FRYL is implicated in, by any mechanism.

Disease | GeneticClinVar

29 pathogenic / likely-pathogenic of 486 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Pan-Chung-Bellen syndrome
  • FRYL-related disorder
  • FRYL-related developmental disorder

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.27
gnomAD pLI
1
gnomAD missense Z
2.96
DepMap mean gene effect
0.1
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of FRYL in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FRYL as an antibody target. Whether an autoantibody or antibody against FRYL could matter depends on whether native FRYL is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FRYL is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FRYL as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/FRYL. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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