Seroatlas · Human Serome Atlas

SARG

Specifically androgen-regulated gene protein

Also known as: C1orf116, FLJ36507, MGC2742, MGC4309, SARG_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9BW04
Gene
SARG
Ensembl
ENSG00000182795
Chromosome
1
Canonical length
601 aa
Protein class
Predicted intracellular proteins
Subcellular location
Plasma membrane,Cytosol

OverviewNCBI Gene

Located in cytosol and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

601 residues, UniProt reviewed canonical sequence.

>Q9BW04|SARG
     1  MPERELWPAG TGSEPVTRVG SCDSMMSSTS TRSGSSDSSY DFLSTEEKEC LLFLEETIGS
    61  LDTEADSGLS TDESEPATTP RGFRALPITQ PTPRGGPEET ITQQGRTPRT VTESSSSHPP
   121  EPQGLGLRSG SYSLPRNIHI ARSQNFRKST TQASSHNPGE PGRLAPEPEK EQVSQSSQPR
   181  QAPASPQEAA LDLDVVLIPP PEAFRDTQPE QCREASLPEG PGQQGHTPQL HTPSSSQERE
   241  QTPSEAMSQK AKETVSTRYT QPQPPPAGLP QNARAEDAPL SSGEDPNSRL APLTTPKPRK
   301  LPPNIVLKSS RSSFHSDPQH WLSRHTEAAP GDSGLISCSL QEQRKARKEA LEKLGLPQDQ
   361  DEPGLHLSKP TSSIRPKETR AQHLSPAPGL AQPAAPAQAS AAIPAAGKAL AQAPAPAPGP
   421  AQGPLPMKSP APGNVAASKS MPISIPKAPR ANSALTPPKP ESGLTLQESN TPGLRQMNFK
   481  SNTLERSGVG LSSYLSTEKD ASPKTSTSLG KGSFLDKISP SVLRNSRPRP ASLGTGKDFA
   541  GIQVGKLADL EQEQSSKRLS YQGQSRDKLP RPPCVSVKIS PKGVPNEHRR EALKKLGLLK
   601  E

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SARG can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.7
Highest tissue expression
98 nTPM

Expression across tissuesHPA

Tissue

  • esophagus: 98 nTPM
  • lung: 69 nTPM
  • stomach: 55 nTPM
  • prostate: 48 nTPM
  • skin: 36 nTPM
  • vagina: 30 nTPM

Single-cell type

  • esophageal apical cells: 749 nCPM
  • ocular epithelial cells: 380 nCPM
  • alveolar cells type 1: 244 nCPM
  • urothelial cells: 220 nCPM
  • transitional alveolar cells: 137 nCPM
  • esophageal suprabasal cells: 128 nCPM

Immune cell

  • total PBMC: 0.2 nTPM
  • neutrophil: 0.1 nTPM
  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM

Brain region

  • cerebral cortex: 0.3 nTPM
  • cerebellum: 0.2 nTPM
  • hippocampal formation: 0.2 nTPM
  • pons: 0.2 nTPM
  • white matter: 0.2 nTPM
  • amygdala: 0.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.73
gnomAD pLI
0
DepMap mean gene effect
0
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SARG in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SARG as an antibody target. Whether an autoantibody or antibody against SARG could matter depends on whether native SARG is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SARG is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SARG as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SARG. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...