Seroatlas · Human Serome Atlas

CENPQ

Centromere protein Q

Also known as: C6orf139, CENP-Q, CENPQ_HUMAN, FLJ10545

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q7L2Z9
Gene: CENPQ
Ensembl: ENSG00000031691
Chromosome: 6
Canonical length: 268 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

CENPQ is a subunit of a CENPH (MIM 605607)-CENPI (MIM 300065)-associated centromeric complex that targets CENPA (MIM 117139) to centromeres and is required for proper kinetochore function and mitotic progression (Okada et al., 2006 [PubMed 16622420]).[supplied by OMIM, Mar 2008]

Canonical amino-acid sequenceUniProt

268 residues, UniProt reviewed canonical sequence.

>Q7L2Z9|CENPQ
     1  MSGKANASKK NAQQLKRNPK RKKDNEEVVL SENKVRNTVK KNKNHLKDLS SEGQTKHTNL
    61  KHGKTAASKR KTWQPLSKST RDHLQTMMES VIMTILSNSI KEKEEIQYHL NFLKKRLLQQ
   121  CETLKVPPKK MEDLTNVSSL LNMERARDKA NEEGLALLQE EIDKMVETTE LMTGNIQSLK
   181  NKIQILASEV EEEEERVKQM HQINSSGVLS LPELSQKTLK APTLQKEILA LIPNQNALLK
   241  DLDILHNSSQ MKSMSTFIEE AYKKLDAS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CENPQ can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.55
Highest tissue expression: 9.4 nTPM

Expression across tissuesHPA

Tissue

spinal cord: 9.4 nTPM
thymus: 8.8 nTPM
tongue: 7.9 nTPM
tonsil: 7.9 nTPM
lymph node: 6.5 nTPM
ovary: 6.5 nTPM

Single-cell type

differentiating spermatogonia: 58 nCPM
oocytes: 55 nCPM
extravillous trophoblasts: 45 nCPM
erythrocyte progenitors: 36 nCPM
early primary spermatocytes: 32 nCPM
adrenal medulla cells: 32 nCPM

Immune cell

naive B-cell: 4.6 nTPM
memory B-cell: 4.4 nTPM
eosinophil: 4.1 nTPM
T-reg: 3.2 nTPM
plasmacytoid DC: 2.7 nTPM
NK-cell: 2.4 nTPM

Brain region

white matter: 11 nTPM
medulla oblongata: 7.4 nTPM
cerebellum: 7 nTPM
basal ganglia: 6.8 nTPM
pons: 6.5 nTPM
spinal cord: 6.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.35
gnomAD pLI: 0
gnomAD missense Z: 0.27
DepMap mean gene effect: -0.12
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

Centromere protein Q
CENP-Q, a CENPA-CAD centromere complex subunit

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CENPQ in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CENPQ as an antibody target. Whether an autoantibody or antibody against CENPQ could matter depends on whether native CENPQ is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CENPQ is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CENPQ as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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