Seroatlas · Human Serome Atlas

TRAF5

TNF receptor-associated factor 5

Also known as: RNF84, TRAF5_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O00463
Gene
TRAF5
Ensembl
ENSG00000082512
Chromosome
1
Canonical length
557 aa
Protein class
Predicted intracellular proteins
Subcellular location
Centrosome,Cytosol
Quaternary structure
Homotrimer

OverviewNCBI Gene

The scaffold protein encoded by this gene is a member of the tumor necrosis factor receptor-associated factor (TRAF) protein family and contains a meprin and TRAF homology (MATH) domain, a RING-type zinc finger, and two TRAF-type zinc fingers. TRAF proteins are associated with, and mediate signal transduction from members of the TNF receptor superfamily. This protein is one of the components of a multiple protein complex which binds to tumor necrosis factor (TNF) receptor cytoplasmic domains and mediates TNF-induced activation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2016]

Canonical amino-acid sequenceUniProt

557 residues, UniProt reviewed canonical sequence.

>O00463|TRAF5
     1  MAYSEEHKGM PCGFIRQNSG NSISLDFEPS IEYQFVERLE ERYKCAFCHS VLHNPHQTGC
    61  GHRFCQHCIL SLRELNTVPI CPVDKEVIKS QEVFKDNCCK REVLNLYVYC SNAPGCNAKV
   121  ILGRYQDHLQ QCLFQPVQCS NEKCREPVLR KDLKEHLSAS CQFRKEKCLY CKKDVVVINL
   181  QNHEENLCPE YPVFCPNNCA KIILKTEVDE HLAVCPEAEQ DCPFKHYGCA VTDKRRNLQQ
   241  HEHSALREHM RLVLEKNVQL EEQISDLHKS LEQKESKIQQ LAETIKKLEK EFKQFAQLFG
   301  KNGSFLPNIQ VFASHIDKSA WLEAQVHQLL QMVNQQQNKF DLRPLMEAVD TVKQKITLLE
   361  NNDQRLAVLE EETNKHDTHI NIHKAQLSKN EERFKLLEGT CYNGKLIWKV TDYKMKKREA
   421  VDGHTVSIFS QSFYTSRCGY RLCARAYLNG DGSGRGSHLS LYFVVMRGEF DSLLQWPFRQ
   481  RVTLMLLDQS GKKNIMETFK PDPNSSSFKR PDGEMNIASG CPRFVAHSVL ENAKNAYIKD
   541  DTLFLKVAVD LTDLEDL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TRAF5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.38
Highest tissue expression
28 nTPM

Expression across tissuesHPA

Tissue

  • lymph node: 28 nTPM
  • tonsil: 26 nTPM
  • blood vessel: 21 nTPM
  • pancreas: 20 nTPM
  • smooth muscle: 19 nTPM
  • fallopian tube: 18 nTPM

Single-cell type

  • choroid plexus epithelial cells: 163 nCPM
  • b-cells: 159 nCPM
  • thymocytes: 122 nCPM
  • podocytes: 111 nCPM
  • tuft cells: 104 nCPM
  • mast cells: 96 nCPM

Immune cell

  • memory B-cell: 22 nTPM
  • NK-cell: 21 nTPM
  • naive B-cell: 20 nTPM
  • T-reg: 18 nTPM
  • MAIT T-cell: 17 nTPM
  • basophil: 14 nTPM

Brain region

  • choroid plexus: 55 nTPM
  • basal ganglia: 8.6 nTPM
  • hippocampal formation: 6.6 nTPM
  • amygdala: 6.4 nTPM
  • cerebral cortex: 5.4 nTPM
  • thalamus: 5.4 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about TRAF5.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 95 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.09
gnomAD pLI
0
gnomAD missense Z
0.96
DepMap mean gene effect
0.01
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TRAF5 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TRAF5 as an antibody target. Whether an autoantibody or antibody against TRAF5 could matter depends on whether native TRAF5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TRAF5 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TRAF5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TRAF5. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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