Seroatlas · Human Serome Atlas

FRAT1

Proto-oncogene FRAT1

Also known as: FRAT1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q92837
Gene: FRAT1
Ensembl: ENSG00000165879
Chromosome: 10
Canonical length: 279 aa
Protein class: Predicted intracellular proteins
Subcellular location: Vesicles,Cytosol

OverviewNCBI Gene

The protein encoded by this gene belongs to the GSK-3-binding protein family. The protein inhibits GSK-3-mediated phosphorylation of beta-catenin and positively regulates the Wnt signaling pathway. It may function in tumor progression and in lymphomagenesis. [provided by RefSeq, Oct 2008]

Canonical amino-acid sequenceUniProt

279 residues, UniProt reviewed canonical sequence.

>Q92837|FRAT1
     1  MPCRREEEEE AGEEAEGEEE EEDSFLLLQQ SVALGSSGEV DRLVAQIGET LQLDAAQHSP
    61  ASPCGPPGAP LRAPGPLAAA VPADKARSPA VPLLLPPALA ETVGPAPPGV LRCALGDRGR
   121  VRGRAAPYCV AELATGPSAL SPLPPQADLD GPPGAGKQGI PQPLSGPCRR GWLRGAAASR
   181  RLQQRRGSQP ETRTGDDDPH RLLQQLVLSG NLIKEAVRRL HSRRLQLRAK LPQRPLLGPL
   241  SAPVHEPPSP RSPRAACSDP GASGRAQLRT GDGVLVPGS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FRAT1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.7
Highest tissue expression: 12 nTPM

Expression across tissuesHPA

Tissue

spleen: 12 nTPM
liver: 12 nTPM
testis: 11 nTPM
bone marrow: 10 nTPM
appendix: 4.7 nTPM
stomach: 4.5 nTPM

Single-cell type

late spermatids: 135 nCPM
neutrophils: 91 nCPM
early spermatids: 38 nCPM
neutrophil progenitors: 32 nCPM
megakaryocytes: 31 nCPM
monocytes: 30 nCPM

Immune cell

neutrophil: 10 nTPM
eosinophil: 8.7 nTPM
classical monocyte: 2 nTPM
non-classical monocyte: 1.5 nTPM
intermediate monocyte: 1.3 nTPM
myeloid DC: 1 nTPM

Brain region

hypothalamus: 7.6 nTPM
cerebellum: 7.5 nTPM
medulla oblongata: 7.1 nTPM
cerebral cortex: 6.9 nTPM
midbrain: 6.8 nTPM
pons: 6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.11
gnomAD pLI: 0.32
gnomAD missense Z: 0.23
DepMap mean gene effect: -0.03
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

molecular function inhibitor activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of FRAT1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FRAT1 as an antibody target. Whether an autoantibody or antibody against FRAT1 could matter depends on whether native FRAT1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FRAT1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FRAT1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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