Seroatlas · Human Serome Atlas

CLNK

Cytokine-dependent hematopoietic cell linker

Also known as: CLNK_HUMAN, MIST

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q7Z7G1
Gene
CLNK
Ensembl
ENSG00000109684
Chromosome
4
Canonical length
428 aa
Protein class
Predicted intracellular proteins
Subcellular location
Vesicles

OverviewNCBI Gene

MIST is a member of the SLP76 family of adaptors (see LCP2, MIM 601603; BLNK, MIM 604515). MIST plays a role in the regulation of immunoreceptor signaling, including PLC-gamma (PLCG1; MIM 172420)-mediated B cell antigen receptor (BCR) signaling and FC-epsilon R1 (see FCER1A, MIM 147140)-mediated mast cell degranulation (Cao et al., 1999 [PubMed 10562326]; Goitsuka et al., 2000, 2001 [PubMed 10744659] [PubMed 11463797]).[supplied by OMIM, Mar 2008]

Canonical amino-acid sequenceUniProt

428 residues, UniProt reviewed canonical sequence.

>Q7Z7G1|CLNK
     1  MNRQGNRKTT KEGSNDLKFQ NFSLPKNRSW PRINSATGQY QRMNKPLLDW ERNFAAVLDG
    61  AKGHSDDDYD DPELRMEETW QSIKILPARP IKESEYADTH YFKVAMDTPL PLDTRTSISI
   121  GQPTWNTQTR LERVDKPISK DVRSQNIKGD ASVRKNKIPL PPPRPLITLP KKYQPLPPEP
   181  ESSRPPLSQR HTFPEVQRMP SQISLRDLSE VLEAEKVPHN QRKPESTHLL ENQNTQEIPL
   241  AISSSSFTTS NHSVQNRDHR GGMQPCSPQR CQPPASCSPH ENILPYKYTS WRPPFPKRSD
   301  RKDVQHNEWY IGEYSRQAVE EAFMKENKDG SFLVRDCSTK SKEEPYVLAV FYENKVYNVK
   361  IRFLERNQQF ALGTGLRGDE KFDSVEDIIE HYKNFPIILI DGKDKTGVHR KQCHLTQPLP
   421  LTRHLLPL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CLNK can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.6
Highest tissue expression
6.1 nTPM

Expression across tissuesHPA

Tissue

  • kidney: 6.1 nTPM
  • lymph node: 2.5 nTPM
  • tonsil: 1.5 nTPM
  • spleen: 1.4 nTPM
  • pituitary gland: 1.2 nTPM
  • epididymis: 1.1 nTPM

Single-cell type

  • renal collecting duct intercalated cells: 2,616 nCPM
  • respiratory ionocytes: 1,052 nCPM
  • salivary ionocytes: 880 nCPM
  • somatotrophs: 626 nCPM
  • epididymal clear cells: 486 nCPM
  • cdc: 313 nCPM

Immune cell

  • myeloid DC: 2 nTPM
  • NK-cell: 1.6 nTPM
  • T-reg: 1.5 nTPM
  • memory B-cell: 1 nTPM
  • naive B-cell: 0.9 nTPM
  • basophil: 0.4 nTPM

Brain region

  • cerebellum: 5.9 nTPM
  • white matter: 4.9 nTPM
  • cerebral cortex: 4.4 nTPM
  • hypothalamus: 4.2 nTPM
  • pons: 4.2 nTPM
  • thalamus: 4.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.77
gnomAD pLI
0
gnomAD missense Z
-0.56
DepMap mean gene effect
0.08
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CLNK in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CLNK as an antibody target. Whether an autoantibody or antibody against CLNK could matter depends on whether native CLNK is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CLNK is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CLNK as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CLNK. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...