Seroatlas · Human Serome Atlas

COPZ1

Coatomer subunit zeta-1

Also known as: CGI-120, COPZ, COPZ1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P61923
Gene
COPZ1
Ensembl
ENSG00000111481
Chromosome
12
Canonical length
177 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

This gene encodes a subunit of the cytoplasmic coatamer protein complex, which is involved in autophagy and intracellular protein trafficking. The coatomer protein complex is comprised of seven subunits and functions as the coat protein of coat protein complex (COP)I-vesicles. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012]

Canonical amino-acid sequenceUniProt

177 residues, UniProt reviewed canonical sequence.

>P61923|COPZ1
     1  MEALILEPSL YTVKAILILD NDGDRLFAKY YDDTYPSVKE QKAFEKNIFN KTHRTDSEIA
    61  LLEGLTVVYK SSIDLYFYVI GSSYENELML MAVLNCLFDS LSQMLRKNVE KRALLENMEG
   121  LFLAVDEIVD GGVILESDPQ QVVHRVALRG EDVPLTEQTV SQVLQSAKEQ IKWSLLR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against COPZ1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.32
Highest tissue expression
142 nTPM

Expression across tissuesHPA

Tissue

  • pancreas: 142 nTPM
  • epididymis: 118 nTPM
  • choroid plexus: 112 nTPM
  • thyroid gland: 108 nTPM
  • liver: 107 nTPM
  • kidney: 106 nTPM

Single-cell type

  • esophageal apical cells: 545 nCPM
  • extravillous trophoblasts: 353 nCPM
  • esophageal suprabasal cells: 311 nCPM
  • migrating cytotrophoblasts: 254 nCPM
  • syncytiotrophoblasts: 227 nCPM
  • hofbauer cells: 207 nCPM

Immune cell

  • plasmacytoid DC: 152 nTPM
  • non-classical monocyte: 135 nTPM
  • total PBMC: 135 nTPM
  • myeloid DC: 128 nTPM
  • classical monocyte: 128 nTPM
  • intermediate monocyte: 118 nTPM

Brain region

  • choroid plexus: 77 nTPM
  • white matter: 54 nTPM
  • thalamus: 51 nTPM
  • hypothalamus: 50 nTPM
  • basal ganglia: 49 nTPM
  • midbrain: 48 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about COPZ1.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 38 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Neutropenia, severe congenital, 12, autosomal recessive

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.34
gnomAD pLI
0.95
gnomAD missense Z
0.77
DepMap mean gene effect
-1.44
DepMap dependency class
pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of COPZ1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads COPZ1 as an antibody target. Whether an autoantibody or antibody against COPZ1 could matter depends on whether native COPZ1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

COPZ1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label COPZ1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/COPZ1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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