Seroatlas · Human Serome Atlas

TEX2

Testis-expressed protein 2

Also known as: HT008, KIAA1738, TEX2_HUMAN, TMEM96

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8IWB9
Gene: TEX2
Ensembl: ENSG00000136478
Chromosome: 17
Canonical length: 1127 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Predicted to enable lipid binding activity. Predicted to be involved in signal transduction and sphingolipid metabolic process. Predicted to be located in membrane. Predicted to be active in endoplasmic reticulum. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1127 residues, UniProt reviewed canonical sequence.

>Q8IWB9|TEX2
     1  MTSLYGRHAE KTTDMPKPSA PKVHVQRSVS RDTIAIHFSA SGEEEEEEEE EFREYFEEGL
    61  DDQSIVTGLE AKEDLYLEPQ VGHDPAGPAA SPVLADGLSV SQAPAILPVS KNTVKLLESP
   121  VPAAQVLSTV PLAVSPGSSS SGPLASSPSV SSLSEQKTSS SSPLSSPSKS PILSSSASTS
   181  TLSSAKPFMS LVKSLSTEVE PKESPHPARH RHLMKTLVKS LSTDTSRQES DTVSYKPPDS
   241  KLNLHLFKQF TQPRNTGGDS KTAPSSPLTS PSDTRSFFKV PEMEAKIEDT KRRLSEVIYE
   301  PFQLLSKIIG EESGSHRPKA LSSSASELSN LSSLNGHLES NNNYSIKEEE CDSEGDGYGS
   361  DSNIPRSDHP KSTGEPTREI ELKSSQGSSL KDLGLKTSSL VLEKCSLSAL VSKEDEEFCE
   421  LYTEDFDLET EGESKVDKLS DIPLKPEVLA EDGVVLDSED EVDSAVQHPE LPVKTLGFFI
   481  MCVYVYLILP LPHYVSGLFL GIGLGFMTAV CVIWFFTPPS AHKYHKLHKN LRHWNTRSLD
   541  IKEPEILKGW MNEIYNYDPE TYHATLTHSV FVRLEGGTLR LSKPNKNISR RASYNEPKPE
   601  VTYISQKIYD LSDSKIYLVP KTLARKRIWN KKYPICIELG QQDDFMSKAQ TDKETSEEKP
   661  PAEGSEDPKK PPRPQEGTRS SQRDQILYLF GRTGREKEEW FRRFILASKL KSEIKKSSGV
   721  SGGKPGLLPA HSRHNSPSGH LTHSRSSSKG SVEEIMSQPK QKELAGSVRQ KMLLDYSVYM
   781  GRCVPQESRS PQRSPLQSAE SSPTAGKKLP EVPPSEEEEQ EAWVNALLGR IFWDFLGEKY
   841  WSDLVSKKIQ MKLSKIKLPY FMNELTLTEL DMGVAVPKIL QAFKPYVDHQ GLWIDLEMSY
   901  NGSFLMTLET KMNLTKLGKE PLVEALKVGE IGKEGCRPRA FCLADSDEES SSAGSSEEDD
   961  APEPSGGDKQ LLPGAEGYVG GHRTSKIMRF VDKITKSKYF QKATETEFIK KKIEEVSNTP
  1021  LLLTVEVQEC RGTLAVNIPP PPTDRVWYGF RKPPHVELKA RPKLGEREVT LVHVTDWIEK
  1081  KLEQEFQKVF VMPNMDDVYI TIMHSAMDPR STSCLLKDPP VEAADQP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TEX2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 2
Mean surface accessibility (rSASA): 0.54
Highest tissue expression: 50 nTPM

Expression across tissuesHPA

Tissue

testis: 50 nTPM
skeletal muscle: 42 nTPM
tongue: 39 nTPM
midbrain: 39 nTPM
thyroid gland: 38 nTPM
spinal cord: 35 nTPM

Single-cell type

retinal pigment epithelial cells: 456 nCPM
neutrophil progenitors: 255 nCPM
myonuclei: 227 nCPM
pdcs: 195 nCPM
pituicytes/fscs: 185 nCPM
monocyte progenitors: 138 nCPM

Immune cell

plasmacytoid DC: 21 nTPM
NK-cell: 3.3 nTPM
classical monocyte: 3.1 nTPM
myeloid DC: 2.9 nTPM
non-classical monocyte: 2 nTPM
memory CD8 T-cell: 1.8 nTPM

Brain region

midbrain: 85 nTPM
hypothalamus: 83 nTPM
basal ganglia: 82 nTPM
thalamus: 82 nTPM
cerebral cortex: 79 nTPM
medulla oblongata: 79 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.5
gnomAD pLI: 0
gnomAD missense Z: 1.52
DepMap mean gene effect: 0
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

lipid binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

Synaptotagmin-like mitochondrial-lipid-binding domain

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TEX2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TEX2 as an antibody target. Whether an autoantibody or antibody against TEX2 could matter depends on whether native TEX2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TEX2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TEX2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...