Seroatlas · Human Serome Atlas

CALM2

Calmodulin-2

Also known as: CALM2_HUMAN, CAMII, PHKD, PHKD2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P0DP24
Gene
CALM2
Ensembl
ENSG00000143933
Chromosome
2
Canonical length
149 aa
Protein class
Disease related genes, Human disease related genes, Metabolic proteins, Predicted intracellular proteins, RAS pathway related proteins

OverviewNCBI Gene

This gene is a member of the calmodulin gene family. There are three distinct calmodulin genes dispersed throughout the genome that encode the identical protein, but differ at the nucleotide level. Calmodulin is a calcium binding protein that plays a role in signaling pathways, cell cycle progression and proliferation. Several infants with severe forms of long-QT syndrome (LQTS) who displayed life-threatening ventricular arrhythmias together with delayed neurodevelopment and epilepsy were found to have mutations in either this gene or another member of the calmodulin gene family (PMID:23388215). Mutations in this gene have also been identified in patients with less severe forms of LQTS (PMID:24917665), while mutations in another calmodulin gene family member have been associated with catecholaminergic polymorphic ventricular tachycardia (CPVT)(PMID:23040497), a rare disorder thought to be the cause of a significant fraction of sudden cardiac deaths in young individuals. Pseudogenes of this gene are found on chromosomes 10, 13, and 17. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2015]

Canonical amino-acid sequenceUniProt

149 residues, UniProt reviewed canonical sequence.

>P0DP24|CALM2
     1  MADQLTEEQI AEFKEAFSLF DKDGDGTITT KELGTVMRSL GQNPTEAELQ DMINEVDADG
    61  NGTIDFPEFL TMMARKMKDT DSEEEIREAF RVFDKDGNGY ISAAELRHVM TNLGEKLTDE
   121  EVDEMIREAD IDGDGQVNYE EFVQMMTAK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CALM2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.35
Highest tissue expression
1,306 nTPM

Expression across tissuesHPA

Tissue

  • hippocampal formation: 1,306 nTPM
  • amygdala: 1,267 nTPM
  • spinal cord: 1,255 nTPM
  • cerebral cortex: 1,194 nTPM
  • midbrain: 1,157 nTPM
  • basal ganglia: 1,079 nTPM

Single-cell type

  • fallopian tube ciliated cells: 429 nCPM
  • fallopian secretory cells: 267 nCPM
  • late primary spermatocytes: 266 nCPM
  • early spermatids: 230 nCPM
  • epididymal efferent duct ciliated cells: 224 nCPM
  • neutrophils: 197 nCPM

Immune cell

  • basophil: 950 nTPM
  • intermediate monocyte: 847 nTPM
  • eosinophil: 780 nTPM
  • non-classical monocyte: 766 nTPM
  • total PBMC: 498 nTPM
  • classical monocyte: 450 nTPM

Brain region

  • white matter: 1,166 nTPM
  • cerebral cortex: 911 nTPM
  • thalamus: 875 nTPM
  • cerebellum: 821 nTPM
  • hippocampal formation: 816 nTPM
  • pons: 810 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about CALM2.

Disease | AllUniProt

Conditions CALM2 is implicated in, by any mechanism.

Disease | GeneticClinVar

20 pathogenic / likely-pathogenic of 235 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.37
gnomAD pLI
0.92
gnomAD missense Z
2.79
DepMap mean gene effect
0.11
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CALM2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CALM2 as an antibody target. Whether an autoantibody or antibody against CALM2 could matter depends on whether native CALM2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CALM2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CALM2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CALM2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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