Seroatlas · Human Serome Atlas

MYCBPAP

MYCBP-associated protein

Also known as: AMAP-1, DKFZp434N1415, MYBPP_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8TBZ2
Gene: MYCBPAP
Ensembl: ENSG00000136449
Chromosome: 17
Canonical length: 984 aa
Protein class: Predicted intracellular proteins
Subcellular location: Vesicles

OverviewNCBI Gene

Predicted to enable clathrin binding activity and phospholipid binding activity. Involved in spermatogenesis. Located in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

984 residues, UniProt reviewed canonical sequence.

>Q8TBZ2|MYCBPAP
     1  MRAPARGTGC CGRSGGRWLA GAAQPRCLWA GGAGQRFMVP GGTMKSLKKD SRLRITPTRL
    61  LEASENVKEK KRAKGPEQPT PTIQEEPEPV SNVLQGDDIL ALAIKKEDLK EQHIPRLTEK
   121  EDKRVITQKF IIRKLKPMDP RRKVCHLVAR PANPDEATKP LDYSGPGDSF DGSDQILPHH
   181  ILGSLQDFKR IALARGNTQL AERIPTSPCL MTLISAEGES KQKAPKEEKR PPWAPPPQHN
   241  FLKNWQRNTA LRKKQQEALS EHLKKPVSEL LMHTGETYRR IQEERELIDC TLPTRRDRKS
   301  WENSGFWSRL EYLGDEMTGL VMTKTKTQRG LMEPITHIRK PHSIRVETGL PAQRDASYRY
   361  TWDRSLFLIY RRKELQRIME ELDFSQQDID GLEVVGKGWP FSAVTVEDYT VFERSQGSSS
   421  EDTAYLGTLA SSSDVSMPIL GPSLLFCGKP ACWIRGSNPQ DKRQVGIAAH LTFETLEGEK
   481  TSSELTVVNN GTVAIWYDWR RQHQPDTFQD LKKNRMQRFY FDNREGVILP GEIKTFTFFF
   541  KSLTAGVFRE FWEFRTHPTL LGGAILQVNL HAVSLTQDVF EDERKVLESK LTAHEAVTVV
   601  REVLQELLMG VLTPERTPSP VDAYLTEEDL FRHRNPPLHY EHQVVQSLHQ LWRQYMTLPA
   661  KAEEARPGDK EHVSPIATEK ASVNAELLPR FRSPISETQV PRPENEALRE SGSQKARVGT
   721  KSPQRKSIME EILVEESPDV DSTKSPWEPD GLPLLEWNLC LEDFRKAVMV LPDENHREDA
   781  LMRLNKAALE LCQKPRPLQS NLLHQMCLQL WRDVIDSLVG HSMWLRSVLG LPEKETIYLN
   841  VPEEQDQKSP PIMEVKVPVG KAGKEERKGA AQEKKQLGIK DKEDKKGAKL LGKEDRPNSK
   901  KHKAKDDKKV IKSASQDRFS LEDPTPDIIL SSQEPIDPLV MGKYTQSLHS EVRGLLDTLV
   961  TDLMVLADEL SPIKNVEEAL RLCR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MYCBPAP can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.54
Highest tissue expression: 62 nTPM

Expression across tissuesHPA

Tissue

testis: 62 nTPM
choroid plexus: 4.9 nTPM
fallopian tube: 4.5 nTPM
ovary: 2.5 nTPM
bone marrow: 1.2 nTPM
cerebellum: 1.2 nTPM

Single-cell type

early spermatids: 257 nCPM
late primary spermatocytes: 233 nCPM
late spermatids: 202 nCPM
respiratory ciliated cells: 87 nCPM
ependymal cells: 54 nCPM
fallopian tube ciliated cells: 40 nCPM

Immune cell

neutrophil: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM

Brain region

choroid plexus: 11 nTPM
medulla oblongata: 9.5 nTPM
cerebellum: 8.6 nTPM
midbrain: 8.4 nTPM
cerebral cortex: 7.9 nTPM
hypothalamus: 7.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.64
gnomAD pLI: 0
gnomAD missense Z: 0.31
DepMap mean gene effect: -0.32
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

Immunoglobulin-like fold
MYCBP-associated protein
MYCBP-associated protein family

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of MYCBPAP in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MYCBPAP as an antibody target. Whether an autoantibody or antibody against MYCBPAP could matter depends on whether native MYCBPAP is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MYCBPAP is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MYCBPAP as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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