Seroatlas · Human Serome Atlas

CALM3

Calmodulin-3

Also known as: CALM3_HUMAN, PHKD, PHKD3

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P0DP25
Gene
CALM3
Ensembl
ENSG00000160014
Chromosome
19
Canonical length
149 aa
Protein class
Disease related genes, Human disease related genes, Metabolic proteins, Predicted intracellular proteins, RAS pathway related proteins

OverviewNCBI Gene

This gene encodes a member of a family of proteins that binds calcium and functions as a enzymatic co-factor. Activity of this protein is important in the regulation of the cell cycle and cytokinesis. Multiple alternatively spliced transcript variants have been observed at this gene. [provided by RefSeq, Aug 2016]

Canonical amino-acid sequenceUniProt

149 residues, UniProt reviewed canonical sequence.

>P0DP25|CALM3
     1  MADQLTEEQI AEFKEAFSLF DKDGDGTITT KELGTVMRSL GQNPTEAELQ DMINEVDADG
    61  NGTIDFPEFL TMMARKMKDT DSEEEIREAF RVFDKDGNGY ISAAELRHVM TNLGEKLTDE
   121  EVDEMIREAD IDGDGQVNYE EFVQMMTAK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CALM3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.35
Highest tissue expression
1,444 nTPM

Expression across tissuesHPA

Tissue

  • cerebral cortex: 1,444 nTPM
  • basal ganglia: 1,076 nTPM
  • hippocampal formation: 917 nTPM
  • amygdala: 869 nTPM
  • cerebellum: 593 nTPM
  • hypothalamus: 577 nTPM

Single-cell type

  • late spermatids: 3,494 nCPM
  • platelets: 2,984 nCPM
  • late primary spermatocytes: 2,116 nCPM
  • early spermatids: 1,769 nCPM
  • hofbauer cells: 1,222 nCPM
  • megakaryocytes: 810 nCPM

Immune cell

  • neutrophil: 438 nTPM
  • eosinophil: 264 nTPM
  • T-reg: 197 nTPM
  • non-classical monocyte: 196 nTPM
  • intermediate monocyte: 196 nTPM
  • basophil: 194 nTPM

Brain region

  • cerebral cortex: 2,548 nTPM
  • white matter: 1,787 nTPM
  • hippocampal formation: 1,759 nTPM
  • basal ganglia: 1,544 nTPM
  • pons: 1,279 nTPM
  • amygdala: 1,226 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about CALM3.

Disease | AllUniProt

Conditions CALM3 is implicated in, by any mechanism.

  • Ventricular tachycardia, catecholaminergic polymorphic, 6 (CPVT6) MIM:618782
  • Long QT syndrome 16 (LQT16) MIM:618782

Disease | GeneticClinVar

8 pathogenic / likely-pathogenic of 213 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Disease | ImmuneIEDB

Conditions an epitope on CALM3 was assayed in.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.36
gnomAD pLI
0.93
gnomAD missense Z
2.98
DepMap mean gene effect
0.14
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CALM3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CALM3 as an antibody target. Whether an autoantibody or antibody against CALM3 could matter depends on whether native CALM3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CALM3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CALM3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CALM3. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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