Seroatlas · Human Serome Atlas

MPHOSPH9

M-phase phosphoprotein 9

Also known as: MPP9, MPP9_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q99550
Gene: MPHOSPH9
Ensembl: ENSG00000051825
Chromosome: 12
Canonical length: 1183 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Golgi apparatus,Plasma membrane,Centrosome,Basal body,Cytosol

OverviewNCBI Gene

Involved in negative regulation of cilium assembly. Located in Golgi apparatus; centriole; and centrosome. Implicated in multiple sclerosis. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1183 residues, UniProt reviewed canonical sequence.

>Q99550|MPHOSPH9
     1  MEEFDLVKTL HKTSSSVGSD ENSLHSLGLN LNTDRSSPHL STNGVSSFSG KTRPSVIQGT
    61  VEVLTSLMQE LQNSGKTDSE LWKNCETRWL QLFNLVEKQC QEQIVAQQEQ FHNQIQHIQE
   121  EIKNLVKLQT SSASLASCEG NSSNKQVSSE SQMGFFSLSS ERNESVIHYP ESTEPEIQQE
   181  MSTSQPDCNV DSCSVSSGYG TFCISELNLY KSKDPKEFME HIDVPKGQYV APAVPAESLV
   241  DGVKNENFYI QTPEECHVSL KEDVSISPGE FEHNFLGENK VSEVYSGKTN SNAITSWAQK
   301  LKQNQPKRAH VEDGGSRSKQ GNEQSKKTPI EKSDFAAATH PRAFYLSKPD ETPNAWMSDS
   361  GTGLTYWKLE EKDMHHSLPE TLEKTFISLS STDVSPNQSN TSNEMKLPSL KDIYYKKQRE
   421  NKQLPERNLT SASNPNHPPE VLTLDPTLHM KPKQQISGIQ PHGLPNALDD RISFSPDSVL
   481  EPSMSSPSDI DSFSQASNVT SQLPGFPKYP SHTKASPVDS WKNQTFQNES RTSSTFPSVY
   541  TITSNDISVN TVDEENTVMV ASASVSQSQL PGTANSVPEC ISLTSLEDPV ILSKIRQNLK
   601  EKHARHIADL RAYYESEINS LKQKLEAKEI SGVEDWKITN QILVDRCGQL DSALHEATSR
   661  VRTLENKNNL LEIEVNDLRE RFSAASSASK ILQERIEEMR TSSKEKDNTI IRLKSRLQDL
   721  EEAFENAYKL SDDKEAQLKQ ENKMFQDLLG EYESLGKEHR RVKDALNTTE NKLLDAYTQI
   781  SDLKRMISKL EAQVKQVEHE NMLSLRHNSR IHVRPSRANT LATSDVSRRK WLIPGAEYSI
   841  FTGQPLDTQD SNVDNQLEET CSLGHRSPLE KDSSPGSSST SLLIKKQRET SDTPIMRALK
   901  ELDEGKIFKN WGTQTEKEDT SNINPRQTET SVNASRSPEK CAQQRQKRLN SASQRSSSLP
   961  PSNRKSSTPT KREIMLTPVT VAYSPKRSPK ENLSPGFSHL LSKNESSPIR FDILLDDLDT
  1021  VPVSTLQRTN PRKQLQFLPL DDSEEKTYSE KATDNHVNHS SCPEPVPNGV KKVSVRTAWE
  1081  KNKSVSYEQC KPVSVTPQGN DFEYTAKIRT LAETERFFDE LTKEKDQIEA ALSRMPSPGG
  1141  RITLQTRLNQ EALEDRLERI NRELGSVRMT LKKFHVLRTS ANL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MPHOSPH9 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.63
Highest tissue expression: 31 nTPM

Expression across tissuesHPA

Tissue

thymus: 31 nTPM
bone marrow: 25 nTPM
retina: 20 nTPM
choroid plexus: 13 nTPM
testis: 12 nTPM
lymph node: 11 nTPM

Single-cell type

myonuclei: 185 nCPM
retinal ganglion cells: 178 nCPM
thyrotrophs: 163 nCPM
retinal pigment epithelial cells: 162 nCPM
cone photoreceptor cells: 157 nCPM
lactotrophs: 140 nCPM

Immune cell

naive CD8 T-cell: 12 nTPM
naive CD4 T-cell: 12 nTPM
basophil: 12 nTPM
gdT-cell: 10 nTPM
NK-cell: 10 nTPM
memory CD8 T-cell: 9.5 nTPM

Brain region

cerebellum: 34 nTPM
choroid plexus: 29 nTPM
cerebral cortex: 24 nTPM
white matter: 22 nTPM
basal ganglia: 21 nTPM
thalamus: 19 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.64
gnomAD pLI: 0
gnomAD missense Z: 0.76
DepMap mean gene effect: -0.06
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

negative regulation of cilium assembly

Cellular components

Protein domainsUniProt · Pfam · InterPro

M-phase phosphoprotein 9

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of MPHOSPH9 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MPHOSPH9 as an antibody target. Whether an autoantibody or antibody against MPHOSPH9 could matter depends on whether native MPHOSPH9 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MPHOSPH9 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MPHOSPH9 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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