Seroatlas · Human Serome Atlas

BMP4

Bone morphogenetic protein 4

Also known as: BMP2B, BMP4_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P12644
Gene
BMP4
Ensembl
ENSG00000125378
Chromosome
14
Canonical length
408 aa
Protein class
Cancer-related genes, Disease related genes, Human disease related genes, Predicted intracellular proteins, Predicted secreted proteins
Secretome location
Secreted to blood
Quaternary structure
Homodimer

OverviewNCBI Gene

This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein regulates heart development and adipogenesis. Mutations in this gene are associated with orofacial cleft and microphthalmia in human patients. The encoded protein may also be involved in the pathology of multiple cardiovascular diseases and human cancers. [provided by RefSeq, Jul 2016]

Canonical amino-acid sequenceUniProt

408 residues, UniProt reviewed canonical sequence.

>P12644|BMP4
     1  MIPGNRMLMV VLLCQVLLGG ASHASLIPET GKKKVAEIQG HAGGRRSGQS HELLRDFEAT
    61  LLQMFGLRRR PQPSKSAVIP DYMRDLYRLQ SGEEEEEQIH STGLEYPERP ASRANTVRSF
   121  HHEEHLENIP GTSENSAFRF LFNLSSIPEN EVISSAELRL FREQVDQGPD WERGFHRINI
   181  YEVMKPPAEV VPGHLITRLL DTRLVHHNVT RWETFDVSPA VLRWTREKQP NYGLAIEVTH
   241  LHQTRTHQGQ HVRISRSLPQ GSGNWAQLRP LLVTFGHDGR GHALTRRRRA KRSPKHHSQR
   301  ARKKNKNCRR HSLYVDFSDV GWNDWIVAPP GYQAFYCHGD CPFPLADHLN STNHAIVQTL
   361  VNSVNSSIPK ACCVPTELSA ISMLYLDEYD KVVLKNYQEM VVEGCGCR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against BMP4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Secreted
Secreted
Yes
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.33
Highest tissue expression
75 nTPM

Expression across tissuesHPA

Tissue

  • choroid plexus: 75 nTPM
  • placenta: 42 nTPM
  • urinary bladder: 27 nTPM
  • rectum: 27 nTPM
  • colon: 24 nTPM
  • vagina: 23 nTPM

Single-cell type

  • retinal pigment epithelial cells: 290 nCPM
  • syncytiotrophoblasts: 45 nCPM
  • fibroblasts: 43 nCPM
  • cytotrophoblasts: 37 nCPM
  • vascular endothelial cells: 25 nCPM
  • basal keratinocytes: 24 nCPM

Immune cell

  • non-classical monocyte: 1.9 nTPM
  • naive CD4 T-cell: 1.3 nTPM
  • intermediate monocyte: 1.1 nTPM
  • memory CD4 T-cell: 0.9 nTPM
  • classical monocyte: 0.6 nTPM
  • naive CD8 T-cell: 0.4 nTPM

Brain region

  • choroid plexus: 65 nTPM
  • cerebellum: 10 nTPM
  • cerebral cortex: 5.3 nTPM
  • white matter: 5.1 nTPM
  • thalamus: 4.3 nTPM
  • pons: 4.1 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about BMP4.

Disease | AllUniProt

Conditions BMP4 is implicated in, by any mechanism.

Disease | GeneticClinVar

18 pathogenic / likely-pathogenic of 300 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.33
gnomAD pLI
0.96
gnomAD missense Z
1.01
DepMap mean gene effect
0
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of BMP4 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads BMP4 as an antibody target. Whether an autoantibody or antibody against BMP4 could matter depends on whether native BMP4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

BMP4 is annotated as secreted, so native BMP4 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label BMP4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/BMP4. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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