Seroatlas · Human Serome Atlas

CRIM1

Cysteine-rich motor neuron 1 protein

Also known as: CRIM1_HUMAN, S52

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NZV1
Gene: CRIM1
Ensembl: ENSG00000150938
Chromosome: 2
Canonical length: 1036 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins, Transporters
Secretome location: Intracellular and membrane

OverviewNCBI Gene

This gene encodes a transmembrane protein containing six cysteine-rich repeat domains and an insulin-like growth factor-binding domain. The encoded protein may play a role in tissue development though interactions with members of the transforming growth factor beta family, such as bone morphogenetic proteins. [provided by RefSeq, Nov 2010]

Canonical amino-acid sequenceUniProt

1036 residues, UniProt reviewed canonical sequence.

>Q9NZV1|CRIM1
     1  MYLVAGDRGL AGCGHLLVSL LGLLLLLARS GTRALVCLPC DESKCEEPRN CPGSIVQGVC
    61  GCCYTCASQR NESCGGTFGI YGTCDRGLRC VIRPPLNGDS LTEYEAGVCE DENWTDDQLL
   121  GFKPCNENLI AGCNIINGKC ECNTIRTCSN PFEFPSQDMC LSALKRIEEE KPDCSKARCE
   181  VQFSPRCPED SVLIEGYAPP GECCPLPSRC VCNPAGCLRK VCQPGNLNIL VSKASGKPGE
   241  CCDLYECKPV FGVDCRTVEC PPVQQTACPP DSYETQVRLT ADGCCTLPTR CECLSGLCGF
   301  PVCEVGSTPR IVSRGDGTPG KCCDVFECVN DTKPACVFNN VEYYDGDMFR MDNCRFCRCQ
   361  GGVAICFTAQ CGEINCERYY VPEGECCPVC EDPVYPFNNP AGCYANGLIL AHGDRWREDD
   421  CTFCQCVNGE RHCVATVCGQ TCTNPVKVPG ECCPVCEEPT IITVDPPACG ELSNCTLTGK
   481  DCINGFKRDH NGCRTCQCIN TEELCSERKQ GCTLNCPFGF LTDAQNCEIC ECRPRPKKCR
   541  PIICDKYCPL GLLKNKHGCD ICRCKKCPEL SCSKICPLGF QQDSHGCLIC KCREASASAG
   601  PPILSGTCLT VDGHHHKNEE SWHDGCRECY CLNGREMCAL ITCPVPACGN PTIHPGQCCP
   661  SCADDFVVQK PELSTPSICH APGGEYFVEG ETWNIDSCTQ CTCHSGRVLC ETEVCPPLLC
   721  QNPSRTQDSC CPQCTDQPFR PSLSRNNSVP NYCKNDEGDI FLAAESWKPD VCTSCICIDS
   781  VISCFSESCP SVSCERPVLR KGQCCPYCIE DTIPKKVVCH FSGKAYADEE RWDLDSCTHC
   841  YCLQGQTLCS TVSCPPLPCV EPINVEGSCC PMCPEMYVPE PTNIPIEKTN HRGEVDLEVP
   901  LWPTPSENDI VHLPRDMGHL QVDYRDNRLH PSEDSSLDSI ASVVVPIIIC LSIIIAFLFI
   961  NQKKQWIPLL CWYRTPTKPS SLNNQLVSVD CKKGTRVQVD SSQRMLRIAE PDARFSGFYS
  1021  MQKQNHLQAD NFYQTV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CRIM1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.48
Highest tissue expression: 154 nTPM

Expression across tissuesHPA

Tissue

placenta: 154 nTPM
blood vessel: 121 nTPM
adipose tissue: 83 nTPM
kidney: 65 nTPM
breast: 55 nTPM
lung: 47 nTPM

Single-cell type

podocytes: 1,935 nCPM
endometrial glandular cells: 1,164 nCPM
epicardial cells: 787 nCPM
vascular smooth muscle cells: 680 nCPM
vascular endothelial cells: 609 nCPM
endometrial luminal cells: 601 nCPM

Immune cell

plasmacytoid DC: 2.1 nTPM
basophil: 1.4 nTPM
gdT-cell: 0.6 nTPM
non-classical monocyte: 0.6 nTPM
eosinophil: 0.5 nTPM
MAIT T-cell: 0.4 nTPM

Brain region

choroid plexus: 129 nTPM
hypothalamus: 97 nTPM
thalamus: 94 nTPM
basal ganglia: 80 nTPM
amygdala: 78 nTPM
medulla oblongata: 71 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.24
gnomAD pLI: 1
gnomAD missense Z: 0.19
DepMap mean gene effect: 0.05
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

Insulin-like growth factor-binding protein, IGFBP
VWFC domain
Growth factor receptor cysteine-rich domain superfamily
von Willebrand factor type C domain
Insulin-like growth factor binding protein
VWC2L-like domain
Antistasin-like domain
Hirudin/antistatin
Cysteine-rich motor neuron 1 protein, C-terminal
Cysteine-rich motor neuron 1
Antistasin family
Cysteine-rich motor neuron 1 protein C-terminal

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CRIM1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CRIM1 as an antibody target. Whether an autoantibody or antibody against CRIM1 could matter depends on whether native CRIM1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CRIM1 is annotated at the cell surface, where native CRIM1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label CRIM1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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