Seroatlas · Human Serome Atlas

SOSTDC1

Sclerostin domain-containing protein 1

Also known as: DAND7, DKFZp564D206, SOSD1_HUMAN, USAG1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6X4U4
Gene: SOSTDC1
Ensembl: ENSG00000171243
Chromosome: 7
Canonical length: 206 aa
Protein class: Predicted secreted proteins
Subcellular location: Nucleoli,Nucleoli rim,Golgi apparatus,Vesicles
Secretome location: Secreted to extracellular matrix

OverviewNCBI Gene

This gene is a member of the sclerostin family and encodes an N-glycosylated, secreted protein with a C-terminal cystine knot-like domain. This protein functions as a bone morphogenetic protein (BMP) antagonist. Specifically, it directly associates with BMPs, prohibiting them from binding their receptors, thereby regulating BMP signaling during cellular proliferation, differentiation, and programmed cell death. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

206 residues, UniProt reviewed canonical sequence.

>Q6X4U4|SOSTDC1
     1  MLPPAIHFYL LPLACILMKS CLAFKNDATE ILYSHVVKPV PAHPSSNSTL NQARNGGRHF
    61  SNTGLDRNTR VQVGCRELRS TKYISDGQCT SISPLKELVC AGECLPLPVL PNWIGGGYGT
   121  KYWSRRSSQE WRCVNDKTRT QRIQLQCQDG STRTYKITVV TACKCKRYTR QHNESSHNFE
   181  SMSPAKPVQH HRERKRASKS SKHSMS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SOSTDC1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.56
Highest tissue expression: 233 nTPM

Expression across tissuesHPA

Tissue

choroid plexus: 233 nTPM
stomach: 57 nTPM
lung: 37 nTPM
kidney: 21 nTPM
breast: 17 nTPM
skin: 16 nTPM

Single-cell type

early spermatids: 22 nCPM
late primary spermatocytes: 9.1 nCPM
proximal tubule cells: 4.1 nCPM
loop of henle epithelial cells: 3.7 nCPM
breast lactating cells: 1.9 nCPM
mucous neck cells: 0.8 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

choroid plexus: 248 nTPM
hippocampal formation: 9 nTPM
cerebral cortex: 8.7 nTPM
basal ganglia: 7.2 nTPM
hypothalamus: 5.8 nTPM
white matter: 5.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.01
gnomAD pLI: 0.16
gnomAD missense Z: 0.66
DepMap mean gene effect: 0.02
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

extracellular space

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SOSTDC1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SOSTDC1 as an antibody target. Whether an autoantibody or antibody against SOSTDC1 could matter depends on whether native SOSTDC1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SOSTDC1 is annotated as secreted, so native SOSTDC1 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label SOSTDC1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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