Seroatlas · Human Serome Atlas

BMPR1A

Bone morphogenetic protein receptor type-1A

Also known as: ACVRLK3, ALK3, BMR1A_HUMAN, CD292

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P36894
Gene
BMPR1A
Ensembl
ENSG00000107779
Chromosome
10
Canonical length
532 aa
Protein class
Cancer-related genes, CD markers, Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Predicted intracellular proteins, Predicted membrane proteins
Subcellular location
Cytosol

OverviewNCBI Gene

The bone morphogenetic protein (BMP) receptors are a family of transmembrane serine/threonine kinases that include the type I receptors BMPR1A and BMPR1B and the type II receptor BMPR2. These receptors are also closely related to the activin receptors, ACVR1 and ACVR2. The ligands of these receptors are members of the TGF-beta superfamily. TGF-betas and activins transduce their signals through the formation of heteromeric complexes with 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

532 residues, UniProt reviewed canonical sequence.

>P36894|BMPR1A
     1  MPQLYIYIRL LGAYLFIISR VQGQNLDSML HGTGMKSDSD QKKSENGVTL APEDTLPFLK
    61  CYCSGHCPDD AINNTCITNG HCFAIIEEDD QGETTLASGC MKYEGSDFQC KDSPKAQLRR
   121  TIECCRTNLC NQYLQPTLPP VVIGPFFDGS IRWLVLLISM AVCIIAMIIF SSCFCYKHYC
   181  KSISSRRRYN RDLEQDEAFI PVGESLKDLI DQSQSSGSGS GLPLLVQRTI AKQIQMVRQV
   241  GKGRYGEVWM GKWRGEKVAV KVFFTTEEAS WFRETEIYQT VLMRHENILG FIAADIKGTG
   301  SWTQLYLITD YHENGSLYDF LKCATLDTRA LLKLAYSAAC GLCHLHTEIY GTQGKPAIAH
   361  RDLKSKNILI KKNGSCCIAD LGLAVKFNSD TNEVDVPLNT RVGTKRYMAP EVLDESLNKN
   421  HFQPYIMADI YSFGLIIWEM ARRCITGGIV EEYQLPYYNM VPSDPSYEDM REVVCVKRLR
   481  PIVSNRWNSD ECLRAVLKLM SECWAHNPAS RLTALRIKKT LAKMVESQDV KI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against BMPR1A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.33
Highest tissue expression
18 nTPM

Expression across tissuesHPA

Tissue

  • blood vessel: 18 nTPM
  • thyroid gland: 18 nTPM
  • colon: 15 nTPM
  • seminal vesicle: 12 nTPM
  • endometrium: 12 nTPM
  • prostate: 12 nTPM

Single-cell type

  • myonuclei: 857 nCPM
  • cardiomyocytes: 587 nCPM
  • prostatic glandular cells: 395 nCPM
  • rod photoreceptor cells: 343 nCPM
  • pituicytes/fscs: 335 nCPM
  • lacrimal acinar cells: 332 nCPM

Immune cell

  • basophil: 0.3 nTPM
  • gdT-cell: 0.3 nTPM
  • MAIT T-cell: 0.2 nTPM
  • memory B-cell: 0.2 nTPM
  • memory CD4 T-cell: 0.2 nTPM
  • memory CD8 T-cell: 0.2 nTPM

Brain region

  • medulla oblongata: 19 nTPM
  • spinal cord: 18 nTPM
  • hypothalamus: 18 nTPM
  • white matter: 18 nTPM
  • midbrain: 17 nTPM
  • cerebellum: 15 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about BMPR1A.

Disease | AllUniProt

Conditions BMPR1A is implicated in, by any mechanism.

  • Juvenile polyposis syndrome (JPS) MIM:174900
  • Polyposis syndrome, mixed hereditary 2 (HMPS2) MIM:610069

Disease | GeneticClinVar

307 pathogenic / likely-pathogenic of 2,743 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.36
gnomAD pLI
0.9
gnomAD missense Z
1.92
DepMap mean gene effect
-0.23
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of BMPR1A in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads BMPR1A as an antibody target. Whether an autoantibody or antibody against BMPR1A could matter depends on whether native BMPR1A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

BMPR1A is annotated at the cell surface, where native BMPR1A is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label BMPR1A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/BMPR1A. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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