Seroatlas · Human Serome Atlas

HTRA3

Serine protease HTRA3

Also known as: HTRA3_HUMAN, Prsp, Tasp

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P83110
Gene
HTRA3
Ensembl
ENSG00000170801
Chromosome
4
Canonical length
453 aa
Protein class
Enzymes, Predicted secreted proteins
Subcellular location
Vesicles
Secretome location
Secreted in other tissues
Quaternary structure
Homotrimer

OverviewNCBI Gene

Enables endopeptidase activity; identical protein binding activity; and serine-type peptidase activity. Involved in proteolysis. Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

453 residues, UniProt reviewed canonical sequence.

>P83110|HTRA3
     1  MQARALLLAA LAALALAREP PAAPCPARCD VSRCPSPRCP GGYVPDLCNC CLVCAASEGE
    61  PCGGPLDSPC GESLECVRGL CRCRWSHAVC GTDGHTYANV CALQAASRRA LQLSGTPVRQ
   121  LQKGACPLGL HQLSSPRYKF NFIADVVEKI APAVVHIELF LRHPLFGRNV PLSSGSGFIM
   181  SEAGLIITNA HVVSSNSAAP GRQQLKVQLQ NGDSYEATIK DIDKKSDIAT IKIHPKKKLP
   241  VLLLGHSADL RPGEFVVAIG SPFALQNTVT TGIVSTAQRE GRELGLRDSD MDYIQTDAII
   301  NYGNSGGPLV NLDGEVIGIN TLKVTAGISF AIPSDRITRF LTEFQDKQIK DWKKRFIGIR
   361  MRTITPSLVD ELKASNPDFP EVSSGIYVQE VAPNSPSQRG GIQDGDIIVK VNGRPLVDSS
   421  ELQEAVLTES PLLLEVRRGN DDLLFSIAPE VVM

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against HTRA3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Secreted
Secreted
Yes
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.31
Highest tissue expression
191 nTPM

Expression across tissuesHPA

Tissue

  • heart muscle: 191 nTPM
  • ovary: 98 nTPM
  • adipose tissue: 64 nTPM
  • breast: 50 nTPM
  • urinary bladder: 47 nTPM
  • blood vessel: 46 nTPM

Single-cell type

  • fibroblasts: 116 nCPM
  • myosatellite cells: 93 nCPM
  • fibro-adipogenic progenitors: 71 nCPM
  • leydig cells: 48 nCPM
  • peritubular myoid cells: 44 nCPM
  • ovarian stromal cells: 39 nCPM

Immune cell

  • neutrophil: 0.1 nTPM
  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM

Brain region

  • choroid plexus: 9.9 nTPM
  • thalamus: 2.8 nTPM
  • basal ganglia: 1.8 nTPM
  • cerebral cortex: 1.4 nTPM
  • hypothalamus: 1.3 nTPM
  • pons: 1.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.23
gnomAD pLI
0
gnomAD missense Z
0.5
DepMap mean gene effect
0.04
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of HTRA3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads HTRA3 as an antibody target. Whether an autoantibody or antibody against HTRA3 could matter depends on whether native HTRA3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

HTRA3 is annotated as secreted, so native HTRA3 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label HTRA3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/HTRA3. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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