Seroatlas · Human Serome Atlas

RGMB

Repulsive guidance molecule B

Also known as: DRAGON, FLJ90406, RGMB_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6NW40
Gene: RGMB
Ensembl: ENSG00000174136
Chromosome: 5
Canonical length: 437 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Nucleoplasm
Quaternary structure: Homooligomer

OverviewNCBI Gene

RGMB is a glycosylphosphatidylinositol (GPI)-anchored member of the repulsive guidance molecule family (see RGMA, MIM 607362) and contributes to the patterning of the developing nervous system (Samad et al., 2005 [PubMed 15671031]).[supplied by OMIM, Apr 2009]

Canonical amino-acid sequenceUniProt

437 residues, UniProt reviewed canonical sequence.

>Q6NW40|RGMB
     1  MGLRAAPSSA AAAAAEVEQR RSPGLCPPPL ELLLLLLFSL GLLHAGDCQQ PAQCRIQKCT
    61  TDFVSLTSHL NSAVDGFDSE FCKALRAYAG CTQRTSKACR GNLVYHSAVL GISDLMSQRN
   121  CSKDGPTSST NPEVTHDPCN YHSHAGAREH RRGDQNPPSY LFCGLFGDPH LRTFKDNFQT
   181  CKVEGAWPLI DNNYLSVQVT NVPVVPGSSA TATNKITIIF KAHHECTDQK VYQAVTDDLP
   241  AAFVDGTTSG GDSDAKSLRI VERESGHYVE MHARYIGTTV FVRQVGRYLT LAIRMPEDLA
   301  MSYEESQDLQ LCVNGCPLSE RIDDGQGQVS AILGHSLPRT SLVQAWPGYT LETANTQCHE
   361  KMPVKDIYFQ SCVFDLLTTG DANFTAAAHS ALEDVEALHP RKERWHIFPS SGNGTPRGGS
   421  DLSVSLGLTC LILIVFL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RGMB can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.36
Highest tissue expression: 39 nTPM

Expression across tissuesHPA

Tissue

stomach: 39 nTPM
skin: 32 nTPM
rectum: 31 nTPM
small intestine: 25 nTPM
cerebral cortex: 24 nTPM
skeletal muscle: 23 nTPM

Single-cell type

paneth cells: 286 nCPM
enteric stem cells: 266 nCPM
parietal cells: 150 nCPM
mucous neck cells: 120 nCPM
gastric chief cells: 118 nCPM
early spermatids: 115 nCPM

Immune cell

naive CD4 T-cell: 3.3 nTPM
T-reg: 2.4 nTPM
naive B-cell: 1.6 nTPM
memory CD4 T-cell: 1.5 nTPM
naive CD8 T-cell: 1.5 nTPM
memory B-cell: 1.1 nTPM

Brain region

pons: 58 nTPM
hypothalamus: 47 nTPM
basal ganglia: 38 nTPM
cerebral cortex: 36 nTPM
midbrain: 34 nTPM
white matter: 31 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.74
gnomAD pLI: 0.07
gnomAD missense Z: 0.71
DepMap mean gene effect: 0.09
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RGMB in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RGMB as an antibody target. Whether an autoantibody or antibody against RGMB could matter depends on whether native RGMB is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RGMB is annotated at the cell surface, where native RGMB is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label RGMB as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...