TGF-beta, propeptide

Definition

This entry represents the propeptide region of TGF-beta that forms LAP. TGF-beta is secreted as a latent complex, consisting of the TGF-beta dimer non-covalently bound to LAP (latency associated peptide) plus a latent TGF-beta binding protein (LTBP). After post-translational processing, TGF-beta binds non-covalently to LAP, a homodimer formed from the propeptide region of TGF-beta, to confer latency PMID:9150447. Latent TGF-beta can then be targeted to the extracellular matrix (ECM) by LTBP. The LAP dimer is usually disulfide-bound to LTBP PMID:15611103.

21 human proteins with this domain

Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.

Download CSV (21 proteins: gene, accession, name)

• BMP10
• BMP2
• BMP4
• BMP5
• BMP6
• BMP7
• BMP8A
• BMP8B
• GDF11
• GDF2
• GDF5
• GDF6
• GDF7
• INHBA
• INHBB
• LEFTY1
• LEFTY2
• MSTN
• TGFB1
• TGFB2
• TGFB3