APC10/DOC domain
IPR004939
Definition
The anaphase-promoting complex (APC) or cyclosome is a multi-subunit E3 protein ubiquitin ligase that regulates important events in mitosis, such as the initiation of anaphase and exit from telophase. The APC, in conjunction with other enzymes, assembles multi-ubiquitin chains on a variety of regulatory proteins, thereby targeting them for proteolysis by the 26S proteasome PMID:18485873. One of the subunits of the APC that is required for ubiquitination activity is APC10, a one-domain protein homologous to a sequence element, termed the DOC domain, found in several hypothetical proteins that may also mediate ubiquitination reactions, because they contain combinations of either RING finger (see [prositedoc:PDOC00449]), cullin (see [prositedoc:PDOC00967]) or HECT (see [prositedoc:PDOC50237]) domains [[cite:PMID:10318877], [cite:PMID:11524682], [cite:PMID:11884135]]. The DOC domain consists of a β-sandwich, in which a five-stranded antiparallel β-sheet is packed on top of a three stranded antiparallel β-sheet, exhibiting a 'jellyroll' fold [[cite:PMID:11524682], [cite:PMID:11884135]]. Proteins known to contain a DOC domain include: Eucaryotic Doc1/Apc10. Mammalian protein associated with the transcription factor Myc (PAM). Mouse runty-jerky-sterile (RJS) protein. Human HERC2, the ortholog of RJS.
7 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
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