Seroatlas · Human Serome Atlas

LTO1

Protein LTO1 homolog

Also known as: CIAB1, LTO1_HUMAN, ORAOV1, TAOS1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8WV07
Gene: LTO1
Ensembl: ENSG00000149716
Chromosome: 11
Canonical length: 137 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Involved in ribosomal large subunit biogenesis and translational initiation. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

137 residues, UniProt reviewed canonical sequence.

>Q8WV07|LTO1
     1  MAGSQDIFDA IVMADERFHG EGYREGYEEG SSLGVMEGRQ HGTLHGAKIG SEIGCYQGFA
    61  FAWKCLLHSC TTEKDSRKMK VLESLIGMIQ KFPYDDPTYD KLHEDLDKIR GKFKQFCSLL
   121  NVQPDFKISA EGSGLSF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LTO1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.43
Highest tissue expression: 19 nTPM

Expression across tissuesHPA

Tissue

pancreas: 19 nTPM
cerebellum: 19 nTPM
spleen: 17 nTPM
skin: 17 nTPM
prostate: 17 nTPM
epididymis: 17 nTPM

Single-cell type

epididymal principal cells: 55 nCPM
adrenal cortex cells: 46 nCPM
adrenal medulla cells: 43 nCPM
retinal horizontal cells: 38 nCPM
oligodendrocytes: 33 nCPM
corticotrophs: 32 nCPM

Immune cell

non-classical monocyte: 7.4 nTPM
T-reg: 6.4 nTPM
naive CD4 T-cell: 6.1 nTPM
memory B-cell: 5.7 nTPM
gdT-cell: 5.5 nTPM
plasmacytoid DC: 5.4 nTPM

Brain region

white matter: 27 nTPM
pons: 21 nTPM
basal ganglia: 20 nTPM
cerebral cortex: 19 nTPM
medulla oblongata: 19 nTPM
thalamus: 19 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.38
gnomAD pLI: 0
DepMap mean gene effect: -1.75
DepMap dependency class: pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 12% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of LTO1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LTO1 as an antibody target. Whether an autoantibody or antibody against LTO1 could matter depends on whether native LTO1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LTO1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label LTO1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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