Seroatlas · Human Serome Atlas

YAE1

Protein YAE1 homolog

Also known as: C7orf36, CIAB2, GK003, YAE1_HUMAN, YAE1D1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NRH1
Gene: YAE1
Ensembl: ENSG00000241127
Chromosome: 7
Canonical length: 226 aa
Protein class: Predicted intracellular proteins
Subcellular location: Cytosol

OverviewNCBI Gene

Predicted to be located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

226 residues, UniProt reviewed canonical sequence.

>Q9NRH1|YAE1
     1  MSWVQAASLI QGPGDKGDVF DEEADESLLA QREWQSNMQR RVKEGYRDGI DAGKAVTLQQ
    61  GFNQGYKKGA EVILNYGRLR GTLSALLSWC HLHNNNSTLI NKINNLLDAV GQCEEYVLKH
   121  LKSITPPSHV VDLLDSIEDM DLCHVVPAEK KIDEAKDERL CENNAEFNKN CSKSHSGIDC
   181  SYVECCRTQE HAHSENPSPT WILEQTASLV KQLGLSVDVL QHLKQL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against YAE1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.5
Highest tissue expression: 22 nTPM

Expression across tissuesHPA

Tissue

ovary: 22 nTPM
epididymis: 21 nTPM
parathyroid gland: 20 nTPM
rectum: 19 nTPM
testis: 19 nTPM
small intestine: 18 nTPM

Single-cell type

late primary spermatocytes: 109 nCPM
oocytes: 83 nCPM
early spermatids: 56 nCPM
oligodendrocyte progenitor cells: 46 nCPM
bergmann glia: 46 nCPM
epididymal principal cells: 45 nCPM

Immune cell

naive CD4 T-cell: 23 nTPM
basophil: 22 nTPM
naive CD8 T-cell: 17 nTPM
memory B-cell: 16 nTPM
naive B-cell: 16 nTPM
T-reg: 16 nTPM

Brain region

cerebellum: 20 nTPM
white matter: 17 nTPM
basal ganglia: 16 nTPM
choroid plexus: 16 nTPM
cerebral cortex: 16 nTPM
hypothalamus: 15 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.08
gnomAD pLI: 0
DepMap mean gene effect: -1.1
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 9% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

protein maturation

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of YAE1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads YAE1 as an antibody target. Whether an autoantibody or antibody against YAE1 could matter depends on whether native YAE1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

YAE1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label YAE1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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