C2H2-type zinc finger domain-containing protein
IPR050636
Definition
This family of proteins includes transcriptional regulators with diverse roles in cellular processes such as transcriptional activation, repression, cell cycle progression, differentiation, apoptosis inhibition, and histone 3'-end pre-mRNA processing. Members of this family are characterized by the presence of C2H2-type zinc finger domains, which facilitate DNA binding and are often involved in interactions with other proteins and RNA complexes. These proteins are implicated in the regulation of gene expression by binding to specific DNA sequences and influencing the chromatin structure. Some members are involved in the epigenetic regulation and play critical roles in development, including oocyte and preimplantation embryo development, as well as X chromosome inactivation. The family also includes proteins that may act as tumor suppressors and participate in chromatin remodeling and sister chromatid cohesion.
14 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
Loading the interactive Seroatlas explorer...