Seroatlas · Human Serome Atlas

ZNF14

Zinc finger protein 14

Also known as: GIOT-4, KOX6, ZNF14_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P17017
Gene
ZNF14
Ensembl
ENSG00000105708
Chromosome
19
Canonical length
642 aa
Protein class
Predicted intracellular proteins, Transcription factors
Subcellular location
Nucleoplasm,Cytosol

OverviewNCBI Gene

The protein encoded by this gene contains a zinc finger and a Kruppel-associated box (KRAB) domain. KRAB domain is known to be involved in the transcriptional repression of a number of zinc finger proteins. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

642 residues, UniProt reviewed canonical sequence.

>P17017|ZNF14
     1  MDSVSFEDVA VNFTLEEWAL LDSSQKKLYE DVMQETFKNL VCLGKKWEDQ DIEDDHRNQG
    61  KNRRCHMVER LCESRRGSKC GETTSQMPNV NINKETFTGA KPHECSFCGR DFIHHSSLNR
   121  HMRSHTGQKP NEYQEYEKQP CKCKAVGKTF SYHHCFRKHE RTHTGVKPYE CKQCGKAFIY
   181  YQPFQRHERT HAGQKPYECK QCGKTFIYYQ SFQKHAHTGK KPYECKQCGK AFICYQSFQR
   241  HKRTHTGEKP YECKQCGKAF SCPTYFRTHE RTHTGEKPYK CKECGKAFSF LSSFRRHKRT
   301  HSGEKPYECK ECGKAFFYSA SFRAHVIIHT GARPYKCKEC GKAFNSSNSC RVHERTHIGE
   361  KPYECKRCGK SFSWSISLRL HERTHTGEKP YECKQCHKTF SFSSSLREHE TTHTGEKPYE
   421  CKQCGKTFSF SSSLQRHERT HNAEKPYECK QCGKAFRCSS YFRIHERSHT GEKPYECKQC
   481  GKVFIRSSSF RLHERTHTGE KPYECKLCGK TFSFSSSLRE HEKIHTGNKP FECKQCGKAF
   541  LRSSQIRLHE RTHTGEKPYQ CKQCGKAFIS SSKFRMHERT HTGEKPYRCK QCGKAFRFSS
   601  SVRIHERSHT GEKPYECKQC GKAFISSSHF RLHERTHMGE KV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF14 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.43
Highest tissue expression
7.8 nTPM

Expression across tissuesHPA

Tissue

  • bone marrow: 7.8 nTPM
  • ovary: 7.6 nTPM
  • thyroid gland: 7.3 nTPM
  • parathyroid gland: 7.1 nTPM
  • breast: 6.8 nTPM
  • lymph node: 6.3 nTPM

Single-cell type

  • adrenal medulla cells: 53 nCPM
  • t-cells: 35 nCPM
  • somatotrophs: 31 nCPM
  • b-cells: 30 nCPM
  • distal convoluted tubule cells: 30 nCPM
  • cone photoreceptor cells: 29 nCPM

Immune cell

  • naive CD4 T-cell: 25 nTPM
  • basophil: 22 nTPM
  • MAIT T-cell: 21 nTPM
  • naive CD8 T-cell: 20 nTPM
  • memory CD4 T-cell: 18 nTPM
  • memory CD8 T-cell: 17 nTPM

Brain region

  • cerebellum: 19 nTPM
  • white matter: 14 nTPM
  • hypothalamus: 12 nTPM
  • basal ganglia: 12 nTPM
  • midbrain: 11 nTPM
  • cerebral cortex: 11 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.25
gnomAD pLI
0.1
gnomAD missense Z
0.36
DepMap mean gene effect
0.11
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ZNF14 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF14 as an antibody target. Whether an autoantibody or antibody against ZNF14 could matter depends on whether native ZNF14 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF14 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF14 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ZNF14. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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