Seroatlas · Human Serome Atlas

ZNF626

Zinc finger protein 626

Also known as: ZN626_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q68DY1
Gene
ZNF626
Ensembl
ENSG00000188171
Chromosome
19
Canonical length
528 aa
Protein class
Predicted intracellular proteins, Transcription factors
Subcellular location
Nucleoplasm,Nuclear membrane,Vesicles

OverviewNCBI Gene

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

528 residues, UniProt reviewed canonical sequence.

>Q68DY1|ZNF626
     1  MGPLQFRDVA IEFSLEEWHC LDTAQRNLYR NVMLENYSNL VFLGITVSKP DLITCLEQGR
    61  KPLTMKRNEM IAKPSVMCSH FAQDLWPEQS MKDSFQKVVL RRYEKCEHDN LQLKKGCISV
   121  DECKVHKEGY NELNQCLTTT PRKICQCDKY VKVLHQFPNS NGQKRGHTGK KPFKYIECGK
   181  AFKQFSTLTT HKKIHTGGKP YKCEECGKAF NHSCSLTRHK KIHTGEKPYK CEECGKAFKH
   241  SSTLTTHKRN HTGEKPYKCD KCGKAFMSSS TLSKHEIIHT EKKPYKCEEC GKAFNRSSTL
   301  TTHKIIHTGE KPYKCEECDK AFKYSYTLTT HKRIHTEDKP YKCEECGKAF KYSSTLTTHK
   361  RIHTGEKPYK CEECGKAFKR SSDLTTHKII HTGEKPYKCE ECGKAFKYSS NLTTHKKIHT
   421  GERPYKCEEC GKAFNQSSIL TTHRRIHTGE KFYKCEECGK AFKCSSNLTT HKKIHTGERP
   481  YKCEECGKAF NQSSILTTHE RIILERNSTN VKNVAKPSSG PHTLLHIR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF626 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.46
Highest tissue expression
21 nTPM

Expression across tissuesHPA

Tissue

  • thyroid gland: 21 nTPM
  • ovary: 20 nTPM
  • parathyroid gland: 19 nTPM
  • breast: 15 nTPM
  • urinary bladder: 13 nTPM
  • lymph node: 11 nTPM

Single-cell type

  • retinal pigment epithelial cells: 8.5 nCPM
  • urothelial cells: 6.7 nCPM
  • syncytiotrophoblasts: 6.6 nCPM
  • breast myoepithelial cells: 6 nCPM
  • extravillous trophoblasts: 5.6 nCPM
  • respiratory ionocytes: 5.1 nCPM

Immune cell

  • neutrophil: 11 nTPM
  • naive B-cell: 11 nTPM
  • NK-cell: 9.8 nTPM
  • memory B-cell: 8.4 nTPM
  • memory CD8 T-cell: 8.2 nTPM
  • memory CD4 T-cell: 7.6 nTPM

Brain region

  • cerebral cortex: 21 nTPM
  • white matter: 21 nTPM
  • choroid plexus: 20 nTPM
  • cerebellum: 19 nTPM
  • basal ganglia: 19 nTPM
  • hypothalamus: 17 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.92
gnomAD pLI
0.41
gnomAD missense Z
-0.65
DepMap mean gene effect
0.19
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF626 as an antibody target. Whether an autoantibody or antibody against ZNF626 could matter depends on whether native ZNF626 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF626 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF626 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ZNF626. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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